Document Detail


Influence of early conditioning exercise on the development of gross cartilage defects and swelling behavior of cartilage extracellular matrix in the equine midcarpal joint.
MedLine Citation:
PMID:  19405897     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the influence of early conditioning exercise on the development of gross cartilage defects and swelling behavior of cartilage extracellular matrix (ECM) in the midcarpal joint of horses. ANIMALS: 12 Thoroughbreds. PROCEDURES: 6 horses underwent early conditioning exercise from birth to 18 months of age (CONDEX group), and 6 horses were used as control animals (PASTEX group). The horses were euthanized at 18 months of age, and the midcarpal joints were harvested. Gross defects of the cartilage surface were classified and mapped. Opposing surfaces of the third and radial carpal bones were used to quantify swelling behavior of the cartilage ECM. RESULTS: A wide range of gross defects was detected in the cartilage on the opposing surfaces of the bones of the midcarpal joint; however, there was no significant difference between the CONDEX and PASTEX groups. Similarly, no significant difference in swelling behavior of the cartilage ECM was evident between the CONDEX and PASTEX groups. CONCLUSIONS AND CLINICAL RELEVANCE: In the study reported here, we did not detect negative influences of early conditioning exercise on the prevalence of gross defects in cartilage of the midcarpal joint or the quality of the cartilage ECM as defined by swelling behavior. These results suggested that early conditioning exercise may be used without negative consequences for the midcarpal joint and the cartilage ECM of the third and radial carpal bones.
Authors:
Woong Kim; Chris E Kawcak; C Wayne McIlwraith; Elwyn C Firth; Brian H McArdle; Neil D Broom
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of veterinary research     Volume:  70     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-01     Completed Date:  2009-06-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  589-98     Citation Subset:  IM    
Affiliation:
Biomaterials Laboratory, Department of Chemical and Materials Engineering, Faculty of Engineering, University of Auckland, Auckland 1142, New Zealand.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carpal Joints / pathology*
Cartilage / pathology*
Cartilage Diseases / etiology,  veterinary*
Case-Control Studies
Extracellular Matrix / pathology*
Female
Horse Diseases / etiology*,  pathology
Horses
Male
Physical Conditioning, Animal / adverse effects*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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