Document Detail

Influence of drugs on blood pressure variability.
MedLine Citation:
PMID:  7707156     Owner:  NLM     Status:  MEDLINE    
AIM: To study the causes of blood pressure variability by using antihypertensive drugs. METHODS: Survey of published studies. RESULTS: The results are sometimes unclear and, for some drugs, contradictory. beta-Adrenoceptor antagonists appear to have no effect on blood pressure variability, whereas alpha-adrenoceptor antagonists and atropine can lessen the amplitude of the variations. Similarly, there is a decrease after the administration of clonidine. Guanfacine, however, which acts on the same central receptors, does not lessen variability. Calcium antagonists do not influence blood pressure variability and the results with angiotensin converting enzyme inhibitors are contradictory. CONCLUSIONS: From these results we conclude that blood pressure variability is not dependent on beta-receptor activity or calcium-mediated mechanisms. It is most likely that both alpha-adrenergic tone and the vagal system have significant effects on blood pressure variability.
D L Clement; M De Buyzere; D D Duprez
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of hypertension. Supplement : official journal of the International Society of Hypertension     Volume:  12     ISSN:  0952-1178     ISO Abbreviation:  J Hypertens Suppl     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1995-05-11     Completed Date:  1995-05-11     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8501422     Medline TA:  J Hypertens Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  S49-53     Citation Subset:  IM    
University Hospital, Department of Cardiovascular Diseases, Gent, Belgium.
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MeSH Terms
Adrenergic alpha-Antagonists / pharmacology
Adrenergic beta-Antagonists / pharmacology
Angiotensin-Converting Enzyme Inhibitors / pharmacology
Antihypertensive Agents / pharmacology*
Atropine / pharmacology
Blood Pressure / drug effects*
Calcium Channel Blockers / pharmacology
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Adrenergic beta-Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 0/Calcium Channel Blockers; 51-55-8/Atropine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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