| Influence of donor and recipient sex mismatch on heart transplant outcomes: analysis of the International Society for Heart and Lung Transplantation Registry. | |
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MedLine Citation:
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PMID: 22418079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Prior studies have presented contradictory results after analyzing associations between donor and recipient sex on survival after heart transplantation and causes of death such as acute rejection (AR) and cardiac allograft vasculopathy (CAV). We used the International Society for Heart and Lung Transplantation (ISHLT) Registry, the largest repository of heart transplant outcomes worldwide, to comprehensively address these questions. METHOD: We studied 60,584 adult recipients of heart transplants performed between 1990 and 2008. Outcomes of interest were overall survival, death-censored allograft survival, AR, and CAV, which were studied using regression models. To assess whether donor/recipient sex mismatch affected outcomes, the experience of male recipients with female vs male donors was compared with that of female recipients with female vs male donors through inclusion of an interaction term between donor and recipient sex. RESULTS: Significant differences were observed between male and female recipients in overall survival and death-censored allograft survival for female vs male donors. Male recipients of female allografts had a 10% increase in adjusted mortality relative to male recipients of male allografts, whereas female recipients of female allografts had a 10% decrease in adjusted mortality relative to female recipients of male allografts (p < 0.0001). Findings were similar for death-censored allograft survival. Differences in the effect of donor sex on AR or CAV between male and female recipients were not significant. CONCLUSIONS: Analysis of the ISHLT data set has demonstrated a strong association between donor/recipient sex mismatch and reduced survival after heart transplantation. |
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Authors:
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Kiran K Khush; Jessica T Kubo; Manisha Desai |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-03-13 |
Journal Detail:
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Title: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Volume: 31 ISSN: 1557-3117 ISO Abbreviation: J. Heart Lung Transplant. Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-04-09 Completed Date: 2012-09-11 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 9102703 Medline TA: J Heart Lung Transplant Country: United States |
Other Details:
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Languages: eng Pagination: 459-66 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Palo Alto, CA 94305, USA. kiran@stanford.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cohort Studies Female Follow-Up Studies Graft Rejection Graft Survival Heart Diseases / mortality*, surgery* Heart Transplantation* Humans International Agencies Kaplan-Meier Estimate Male Middle Aged Registries Retrospective Studies Sex Characteristics* Survival Rate Tissue Donors* Transplantation* Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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K23 HL091143/HL/NHLBI NIH HHS; K23 HL091143-01A1/HL/NHLBI NIH HHS; K23HL091143/HL/NHLBI NIH HHS |
| Comments/Corrections | |
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