Document Detail

Influence of dobutamine on regional myocardial blood flow and ventricular performance during acute and chronic myocardial ischemia in dogs.
MedLine Citation:
PMID:  1260986     Owner:  NLM     Status:  MEDLINE    
The data from this study document that dobutamine is a powerful inotropic agent in anesthetized dogs with acute myocardial ischemia and in awake, unsedated ones with chronic myocardial infarction. Dobutamine significantly increases heart rate at relatively small doses in anesthetized dogs with acute myocardial ischemia but considerably larger amounts of dobutamine are required to significantly increase heart rate in awake, unsedated dogs with myocardial infarction. Dobutamine also significantly increases regional myocardial blood flow to all areas of the heart at 20mug/kg/min in both anesthetized dogs with acute myocardial ischemia and awake, unsedated ones with myocardial infarction. However, in anesthetized dogs 20mug/kg/min of dobutamine significantly increases epicardial ST-segment elevation during acute myocardial ischemia. Propranolol prevents the inotropic and chronotropic effects of dobutamine in both anesthetized and awake, unsedated dogs. This study suggests that during experimental acute myocardial ischemia dobutamine given at doses that significantly increase heart rate and contractility may increase the extent of myocardial damage. The data also suggest that this agent should be of value in the setting of severe myocardial depression without associated severe coronary artery disease to increase cardiac contractility at doses that do not markedly alter heart rate. The hemodynamic and coronary blood flow effects of dobutamine in patients with and without severe coronary artery disease should be evaluated.
J T Willerson; I Hutton; J T Watson; M R Platt; G H Templeton
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  53     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1976 May 
Date Detail:
Created Date:  1976-07-06     Completed Date:  1976-07-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  828-33     Citation Subset:  AIM; IM    
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MeSH Terms
Acute Disease
Blood Pressure / drug effects
Catecholamines / pharmacology*
Chronic Disease
Coronary Circulation / drug effects*
Coronary Disease / drug therapy,  physiopathology*
Coronary Vessels / drug effects
Dobutamine / pharmacology*,  therapeutic use
Heart / physiopathology*
Heart Rate / drug effects
Myocardial Contraction / drug effects
Myocardial Infarction / drug therapy,  physiopathology
Propranolol / pharmacology
Reg. No./Substance:
0/Catecholamines; 34368-04-2/Dobutamine; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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