Document Detail


Influence of dipeptide derivatives of S-substituted cysteines on the time of fibrinolysis.
MedLine Citation:
PMID:  9020554     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Amino acids containing sulphur, dipeptide derivatives of methionine and S-substituted derivatives of cysteine are potent antifibrinolytic agents. The structural moiety of the substances responsible for the effect on the clot formation is not known. Present study was undertaken in order to evaluate the effect of some analogues of dipeptides containing S-substituted derivatives of cysteine with the formula A-Cys(S-X)-Y (where A-amino acid, X-benzyl, butyl, hexyl, nonyl and Y-OH or OMe) on clot dissolution under the antifibrinolytic test conditions. It has been found that dipeptide derivatives of S-substituted cysteine (except benzyl derivative) at low concentration evoke antifibrynolytic activity, while at high concentration they prevent clot formation. The results suggest that antifibrinolytic activity of tested compounds at low concentration may be due to the formation of antifibrinolitycally active conformation, while high concentration overcome the effect.
Authors:
K Midura-Nowaczek; I Bruzgo; W Roszkowska-Jakimiec; K Worowski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Roczniki Akademii Medycznej w Białymstoku (1995)     Volume:  41     ISSN:  -     ISO Abbreviation:  Rocz. Akad. Med. Bialymst.     Publication Date:  1996  
Date Detail:
Created Date:  1997-03-06     Completed Date:  1997-03-06     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  9515551     Medline TA:  Rocz Akad Med Bialymst     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  412-6     Citation Subset:  IM    
Affiliation:
Institute of Chemistry, University of Warsaw, Białystok Branch.
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MeSH Terms
Descriptor/Qualifier:
Antifibrinolytic Agents / chemistry,  pharmacology*
Cysteine / analogs & derivatives*,  chemistry
Dipeptides / chemistry*
Fibrinolysis / drug effects*
Molecular Conformation
Whole Blood Coagulation Time
Chemical
Reg. No./Substance:
0/Antifibrinolytic Agents; 0/Dipeptides; 52-90-4/Cysteine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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