| Influence of diltiazem on the ocular irritative response to nitrogen mustard. | |
| | |
MedLine Citation:
|
PMID: 7556484 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Application of nitrogen mustard to the eye of rabbits causes an anterior segment irritation and a biphasic elevation of intraocular pressure. This intraocular pressure response is composed of an initial peak, produced by neuropeptides released by excited sensory nerves, and a second, slower rise due to prostaglandins. We studied the effect of diltiazem, a calcium antagonist that selectively blocks chemical excitation of sensory nerves, on the inflammatory response to nitrogen mustard. In adult rabbits, intraocular pressure was determined by pneumatonometry; pupil diameter and palpebral opening were measured with a ruler while conjunctival vasodilation, edema and secretion were scored in subjective units (0-8). Aqueous humor protein content was analysed at the end of the experiment. Bilateral application of 1% nitrogen mustard evoked within the first 6 hr an intraocular pressure elevation followed by ocular hypotony, miosis, palpebral closure, conjunctival vasodilation, edema and an elevation of aqueous proteins. Topical application of 10 mM diltiazem, prior to administration of nitrogen mustard elicited by itself a transient, small intraocular pressure increase and reduced significantly the acute intraocular pressure elevation and conjunctival vasodilation evoked by the irritant; delayed conjunctival edema and palpebral closure were also attenuated by 10 mM diltiazem. The decrease of miotic response and of aqueous humor protein content was not significant. Diltiazem at 2.8 mM was effective only in reducing significantly conjunctival edema and vasodilation.(ABSTRACT TRUNCATED AT 250 WORDS) |
| | |
Authors:
|
G G Gonzalez; J Gallar; C Belmonte |
Related Documents
:
|
6187704 - Pressure-induced fast axonal transport abnormalities and the anatomy at the lamina crib... 11858614 - Effects of topical natural ergot alkaloids on intraocular pressure and aqueous humor dy... 6153174 - Failure of unilateral carotid artery ligation to affect pressure-induced interruption o... 3277664 - A double-crossover trial comparing the effects of topical carteolol and placebo on intr... 10407464 - The evolution of human speech: the role of enhanced breathing control. 4062924 - Central effects of d-ala2-met-enkephalinamide on the blood pressure of rats after centr... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Experimental eye research Volume: 61 ISSN: 0014-4835 ISO Abbreviation: Exp. Eye Res. Publication Date: 1995 Aug |
Date Detail:
|
Created Date: 1995-11-20 Completed Date: 1995-11-20 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0370707 Medline TA: Exp Eye Res Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 205-12 Citation Subset: IM |
Affiliation:
|
Departamento de Fisiología, Universidad de Alicante, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Topical Animals Diltiazem / pharmacology, therapeutic use* Endophthalmitis / chemically induced, prevention & control* Eye / drug effects Injections, Intravenous Intraocular Pressure / drug effects Mechlorethamine / antagonists & inhibitors*, toxicity Ocular Hypertension / chemically induced, prevention & control* Rabbits |
| Chemical | |
Reg. No./Substance:
|
42399-41-7/Diltiazem; 51-75-2/Mechlorethamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Reorganization of actin microfilaments and microtubules in regenerating retinal pigment epithelium.
Next Document: Effect of pH on the ocular distribution of a topical carbonic anhydrase inhibitor.