Document Detail

Influence of diltiazem on bronchoconstriction induced by cold air breathing during exercise.
MedLine Citation:
PMID:  6382673     Owner:  NLM     Status:  MEDLINE    
Since the calcium antagonists nifedipine and verapamil have been shown to diminish exercise induced asthma, the effect of oral diltiazem, a calcium channel blocker not previously investigated in this context, was studied. Ten patients with bronchial asthma were given 60 mg diltiazem or placebo four hours before the challenge in a double blind, randomised, crossover fashion. Exercise was performed on a cycle ergometer while the subjects were breathing cold air, resulting in a respiratory heat exchange which was similar at the two study sessions. FEV1 and specific conductance (sGaw) were recorded before and three, 10, 15, and 30 minutes after the challenge. No significant differences were found between placebo and diltiazem days in the fall of FEV1 or sGaw after exercise. Thus unlike other calcium antagonists diltiazem, in a dose of 60 mg given orally four hours before exercise, failed to protect against exercise induced asthma.
H Magnussen; V Hartmann; G Reuss
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thorax     Volume:  39     ISSN:  0040-6376     ISO Abbreviation:  Thorax     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-10-10     Completed Date:  1984-10-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  579-82     Citation Subset:  IM    
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MeSH Terms
Airway Resistance / drug effects
Asthma / prevention & control*
Asthma, Exercise-Induced / physiopathology,  prevention & control*
Benzazepines / therapeutic use*
Clinical Trials as Topic
Cold Temperature*
Diltiazem / therapeutic use*
Double-Blind Method
Forced Expiratory Volume
Random Allocation
Reg. No./Substance:
0/Benzazepines; 42399-41-7/Diltiazem

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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