| Influence of different occupations with possible mutagenic effects on reproduction and level of induced chromosomal aberrations in peripheral blood. | |
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MedLine Citation:
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PMID: 1370115 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a group of 200 dysfertile couples (400 persons), the possible role of different occupations in failures of reproduction was assessed. These couples were examined from different points of view, classical genetic examination (pedigree, kayrotype, etc.) included. The suspected genotoxic effects in the personal history were checked also by testing the level of induced chromosomal aberrations. A significantly increased level of induced chromosomal aberrations was detected in 37 persons, i.e., 9.3% of the whole group under study. The average level of induced aberration in these subjects was 6.8%, as opposed to the control group (fertile and dysfertile persons without any unusual exposure to mutagens) with a mean of 1.58% aberrant cells in peripheral blood. Most of the occupations with demonstrated genotoxic effects involve daily contact with chemicals of different types. In some persons also intensive therapy in the recent past had genotoxic effects. |
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Authors:
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M Kucerová; V Gregor; J Horácek; M Dolanská; S Matĕjcková |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Mutation research Volume: 278 ISSN: 0027-5107 ISO Abbreviation: Mutat. Res. Publication Date: 1992 Jan |
Date Detail:
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Created Date: 1992-01-23 Completed Date: 1992-01-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0400763 Medline TA: Mutat Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 19-22 Citation Subset: IM |
Affiliation:
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Department of Genetics, Postgraduate Medical Institute, Prague, Czech and Slovac Federative Republic. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chromosome Aberrations* Female Humans Infertility / blood, etiology* Male Mutagens / adverse effects* Occupational Exposure* Reproduction / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Mutagens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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