Document Detail

Influence of different occupations with possible mutagenic effects on reproduction and level of induced chromosomal aberrations in peripheral blood.
MedLine Citation:
PMID:  1370115     Owner:  NLM     Status:  MEDLINE    
In a group of 200 dysfertile couples (400 persons), the possible role of different occupations in failures of reproduction was assessed. These couples were examined from different points of view, classical genetic examination (pedigree, kayrotype, etc.) included. The suspected genotoxic effects in the personal history were checked also by testing the level of induced chromosomal aberrations. A significantly increased level of induced chromosomal aberrations was detected in 37 persons, i.e., 9.3% of the whole group under study. The average level of induced aberration in these subjects was 6.8%, as opposed to the control group (fertile and dysfertile persons without any unusual exposure to mutagens) with a mean of 1.58% aberrant cells in peripheral blood. Most of the occupations with demonstrated genotoxic effects involve daily contact with chemicals of different types. In some persons also intensive therapy in the recent past had genotoxic effects.
M Kucerová; V Gregor; J Horácek; M Dolanská; S Matĕjcková
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mutation research     Volume:  278     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-01-23     Completed Date:  1992-01-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  19-22     Citation Subset:  IM    
Department of Genetics, Postgraduate Medical Institute, Prague, Czech and Slovac Federative Republic.
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MeSH Terms
Chromosome Aberrations*
Infertility / blood,  etiology*
Mutagens / adverse effects*
Occupational Exposure*
Reproduction / drug effects
Reg. No./Substance:

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