Document Detail

Influence of dietary vitamin K intake on subtherapeutic oral anticoagulant therapy.
MedLine Citation:
PMID:  20151978     Owner:  NLM     Status:  MEDLINE    
It is unclear what advice should be given to patients using vitamin K antagonists with respect to dietary vitamin K intake. We performed a nested case-control study in patients attending a Dutch anticoagulation clinic, to determine the association between vitamin K intake and subtherapeutic International Normalized Ratio (INR) values and the interaction between usual and recent vitamin K intake. Compared to patients with a normal usual vitamin K intake, those with a high vitamin K intake had a decreased risk of a subtherapeutic INR [Hazard Ratio (HR) 0.80, 95% confidence interval (CI): 0.56-1.16] and patients with a low vitamin K intake an increased risk (HR 1.33, 95% CI: 0.79-2.25). In patients with a low usual vitamin K intake, recent vitamin K intake was twice as high in cases as in controls (164 vs. 85 microg/d). Such a difference was not observed in patients with a normal or high usual vitamin K intake. Our results suggest that a high vitamin K intake reduces the risk of a low INR by lessening the influence of incidental consumption of vitamin K rich food on the INR. These findings support the recommendation for patients on vitamin K antagonists to eat a sufficient amount of vitamin-K containing foods.
Eva K Rombouts; Frits R Rosendaal; Felix J M van der Meer
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Publication Detail:
Type:  Journal Article     Date:  2010-02-11
Journal Detail:
Title:  British journal of haematology     Volume:  149     ISSN:  1365-2141     ISO Abbreviation:  Br. J. Haematol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-04     Completed Date:  2010-07-09     Revised Date:  2011-04-20    
Medline Journal Info:
Nlm Unique ID:  0372544     Medline TA:  Br J Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  598-605     Citation Subset:  IM    
Department of Thrombosis and Haemostasis, Leiden University Medical Centre, Leiden, The Netherlands.
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MeSH Terms
Administration, Oral
Anticoagulants / pharmacology*
Blood Coagulation / drug effects
Case-Control Studies
Drug Interactions
International Normalized Ratio
Middle Aged
Vitamin K / administration & dosage,  antagonists & inhibitors,  pharmacology*
Reg. No./Substance:
0/Anticoagulants; 12001-79-5/Vitamin K
Comment In:
Br J Haematol. 2011 Apr;153(1):129-30   [PMID:  21275964 ]

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