Document Detail

Influence of dietary protein levels on survival of rats following kidney irradiation.
MedLine Citation:
PMID:  7107425     Owner:  NLM     Status:  MEDLINE    
Concern about radiation induced nephropathy results in a dose limiting constraint in some applications of radiation therapy. An understanding of the etiology of radiation therapy. An understanding of the etiology of radiation nephropathy is essential if attempts to alter the time course or extent of the pathology are to be successful. In an attempt to gain a better understanding of this disease process, and to see if it could be altered by dietary manipulation, young adult male Sprague-Dawley rats were unilaterally nephrectomized, after which the remaining kidney was exteriorized and exposed to 14 Gy of X rays. Non-irradiated control animals had their remaining kidney exteriorized for a comparable length of time. Five days after irradiation, the animals were switched from standard lab rations to isocaloric diets of differing protein content. Diets used included 4%, 20% and 50% protein and the 4% and 20% diets given in combination with 0.9% NaCl drinking water. For all the diet groups, irradiated animals had median survival times shorter than their corresponding non-irradiated controls. Within the irradiated groups, the ranking of the median survival times was: 4% + 0.9% NaCl greater than 4% greater than 20% + 0.9% NaCl = 20% greater than 50%. The differences in survival among the irradiated groups were significant at the 0.01 level. These data indicate that kidney response to irradiation can be altered by manipulation of dietary protein levels. Such information may have clinical application.
P A Mahler; M B Yatvin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of radiation oncology, biology, physics     Volume:  8     ISSN:  0360-3016     ISO Abbreviation:  Int. J. Radiat. Oncol. Biol. Phys.     Publication Date:  1982 May 
Date Detail:
Created Date:  1982-10-21     Completed Date:  1982-10-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7603616     Medline TA:  Int J Radiat Oncol Biol Phys     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  931-5     Citation Subset:  IM    
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MeSH Terms
Dietary Proteins / therapeutic use*
Kidney / radiation effects*
Radiation Injuries, Experimental / prevention & control*
Rats, Inbred Strains
Grant Support
5 T32 CA 09206/CA/NCI NIH HHS; P01-19278//PHS HHS
Reg. No./Substance:
0/Dietary Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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