Document Detail

Influence of dietary fats on blood coagulation and prostaglandin production in the common marmoset.
MedLine Citation:
PMID:  3107535     Owner:  NLM     Status:  MEDLINE    
Common marmosets were fed a standard marmoset diet (REF) or diets supplemented with 12% (wt/wt) sunflower seed oil (SSO) or sheep fat (SF) for a period of 90 weeks. The values for coagulation indices, clotting time, and Russel viper venom time were consistent with decreased thrombotic tendency of platelets from animals on the SSO diet relative to the low fat, REF diet animals, while an increased tendency to thrombosis was observed with SF-fed marmosets. The SSO- and SF-supplemented marmosets showed a significantly reduced thromboxane (TXB2) generation from platelets aggregating to collagen (ASC) relative to the REF group, while at 50 micrograms/ml ASC this difference was maintained only by the SSO group. The SF diet-fed marmosets showed a reduced prostacyclin (measured as 6-keto-PGF1 alpha) generation from incubated aorta relative to the REF or SSO-fed groups, which were not different from each other. A reduced proportion of platelet phospholipid arachidonic acid (20:4, n-6) and increased alpha-tocopherol concentration was consistent with the decreased aggregability and thromboxane generation of platelets from SSO-fed marmosets relative to the REF and SF groups. The SF diet-fed marmosets, on the other hand, showed minimal change in arachidonic acid, alpha-tocopherol or platelet reactivity from the REF group. These differing responses to dietary fats are discussed in relation to the potential for the development of thrombosis and atherosclerosis.
G H McIntosh; E J McMurchie; M James; C A Lawson; F H Bulman; J S Charnock
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arteriosclerosis (Dallas, Tex.)     Volume:  7     ISSN:  0276-5047     ISO Abbreviation:  Arteriosclerosis     Publication Date:    1987 Mar-Apr
Date Detail:
Created Date:  1987-05-27     Completed Date:  1987-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8401388     Medline TA:  Arteriosclerosis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  159-65     Citation Subset:  IM    
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MeSH Terms
Arachidonic Acid
Arachidonic Acids / metabolism
Blood Coagulation*
Cholesterol / metabolism
Dietary Fats / metabolism*
Epoprostenol / biosynthesis
Phospholipids / metabolism
Platelet Aggregation
Prostaglandins / biosynthesis*
Thromboxane B2 / biosynthesis
Vitamin E / metabolism
Reg. No./Substance:
0/Arachidonic Acids; 0/Dietary Fats; 0/Phospholipids; 0/Prostaglandins; 1406-18-4/Vitamin E; 35121-78-9/Epoprostenol; 506-32-1/Arachidonic Acid; 54397-85-2/Thromboxane B2; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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