Document Detail


Influence of dietary cis- and trans-fat on 1,2-dimethylhydrazine-induced colon tumors and fecal steroid excretion in Fischer 344 rats.
MedLine Citation:
PMID:  4041127     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To investigate the effects of the difference in the geometry of dietary fatty acids on colon tumorigenesis, male rats were fed semipurified diets containing either partially hydrogenated corn oil (trans-monoene fat) or olive oil (cis-monoene fat) at the 10% level and received a single oral dosage of 1,2-dimethylhydrazine (DMH). The difference in the fatty acid composition of dietary fats was confined essentially to the geometrical isomerism of octadecenoate, and the linoleic acid content was made equivalent (2% of total energy). After about 15 mo of feeding, colon tumor incidence in DMH treated rats was nearly the same in both fat groups. Fecal neutral steroid excretion was higher, while the transformation of cholesterol to coprostanol was lower in rats given the trans-fat. There were no marked differences in the excretion and composition of fecal bile acids between two fat groups. Serum cholesterol and tocopherol levels of rats given trans-fat diets tended to be low. The results suggested that the trans-monoene behaves much like the cis-monoene in the incidence of DMH-induced colon tumors, although there were characteristic differences in metabolic events in the intestine.
Authors:
M Watanabe; T Koga; M Sugano
Related Documents :
3955537 - Effects of four antioxidants on n-methyl-n'-nitro-n-nitrosoguanidine initiated gastric ...
12065087 - A bitter diterpenoid furanolactone columbin from calumbae radix inhibits azoxymethane-i...
9498277 - Effect of bifidobacterium longum and inulin on gut bacterial metabolism and carcinogen-...
9276627 - Influence of diets containing high and low risk factors for colon cancer on early stage...
12591197 - Enhancing immunity to nematode parasites in single-bearing merino ewes through nutritio...
9601487 - Renal, intestinal, and adrenal responses to sodium loading in dahl-iwai salt-sensitive ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  42     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1985 Sep 
Date Detail:
Created Date:  1985-10-09     Completed Date:  1985-10-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  475-84     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
1,2-Dimethylhydrazine
Animals
Cholesterol / blood
Colonic Neoplasms / chemically induced,  pathology*
Dietary Fats / pharmacology*
Dimethylhydrazines
Fatty Acids / analysis
Feces / analysis*
Lipids / analysis
Liver / analysis
Male
Rats
Rats, Inbred F344
Steroids / metabolism*
Vitamin A / blood
Vitamin E / blood
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Dimethylhydrazines; 0/Fatty Acids; 0/Lipids; 0/Steroids; 11103-57-4/Vitamin A; 1406-18-4/Vitamin E; 540-73-8/1,2-Dimethylhydrazine; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Studies on the 4-carbon compound needed for the formation of the O-xylene ring of riboflavin.
Next Document:  Vitamin B6, vitamin C and folacin levels in milk from mothers of term and preterm infants during the...