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Influence of dietary carnitine in growing sheep fed diets containing non-protein nitrogen.
MedLine Citation:
PMID:  11259872     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The influence of supplemental L-carnitine was investigated in growing sheep fed rations containing non-protein nitrogen (NPN). The experiment was conducted as a randomized block design with a 2x2 factorial arrangement of treatments. Lambs (77.4kg BW, n=24) were fed a total mixed ration (12.1-13.6% CP) with two levels of L-carnitine (0 or 250ppm) and two levels of NPN (urea contributing 0 or 50% of total dietary N) for a 50-day period. Jugular blood samples were collected at 0, 1, and 3h post-feeding, and ruminal fluid samples were collected at 1h post-feeding, during days 1, 8, 29, and 50 of the experiment. Average daily gain (121 versus 214g) was lower (P<0.0001) in lambs fed the NPN diets. Lambs consuming diets containing NPN had higher (P<0.0001) ruminal fluid pH (6.6 versus 5.9), ruminal ammonia N (4.8 versus 2.8mmol/l), and plasma ammonia N (177.1 versus 49.5µmol/l) than lambs not fed NPN. Additionally, lambs fed the NPN diets had lower plasma urea N (14.5 versus 17.5mmol/l; P<0.003) and thyroxine (T(4)) concentrations (65.8 versus 78.4ng/ml; P<0.02), and lower T(4):triiodothyronine (T(3)) ratio (37.9 versus 43.9; P<0.02). Plasma glucose concentrations were higher (P<0.05) in lambs fed L-carnitine (3.83 versus 3.70mmol/l). Two oral urea load tests (OULT 1 and OULT 2) were conducted during the 50-day trial. Urea solutions (0.835g/kg(0.75) BW) were administered as oral drenches. During the OULT 1 (day 10), plasma ammonia N and glucose concentrations were highest (P<0.0001) in the lambs fed NPN with L-carnitine compared with lambs fed control, L-carnitine, and NPN diets. During the OULT 2 (day 50), plasma ammonia N was highest (P<0.0001) in the NPN and NPN with L-carnitine groups compared with the control and L-carnitine groups. Plasma glucose was lowest (P<0.04) in the NPN with L-carnitine group compared with the NPN and L-carnitine groups, but did not differ (P>0.10) from the control group. Plasma urea N levels in both OULT 1 and OULT 2 were lower (P<0.0001) in the NPN and NPN with L-carnitine groups compared with the control and L-carnitine groups. In the present experiment, production and plasma criteria were affected by NPN incorporation in the diets. Production criteria were not affected by inclusion of L-carnitine in the diet, however, L-carnitine reduced experimentally induced hyperammonemia by day 50 of the trial.
Authors:
A M. Chapa; J M. Fernandez; T W. White; L D. Bunting; L R. Gentry; J C. Lovejoy; K Q. Owen
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Small ruminant research : the journal of the International Goat Association     Volume:  40     ISSN:  -     ISO Abbreviation:  Small Rumin. Res.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-Mar-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9885624     Medline TA:  Small Rumin Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  13-28     Citation Subset:  -    
Affiliation:
Department of Animal Science, Louisiana State University Agricultural Center, 70803-4210, Baton Rouge, LA, USA
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