| Influence of diet complexity on intestinal adaptation following massive small bowel resection in a preclinical model. | |
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MedLine Citation:
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PMID: 12453276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To investigate the effect of dietary complexity on intestinal adaptation using a preclinical model. METHODS: Four-week-old piglets underwent a 75% proximal small bowel resection or transection operation (control). Post-operatively, animals received either pig chow (n = 15), polymeric formula (n = 9), polymeric formula plus fiber (n = 6), or elemental formula (n = 7). RESULTS: The weight gain of all groups was reduced compared with controls that were fed the same diet. Animals that had a resection, which were fed elemental formula, had significantly reduced weight gain compared with the other groups (4.7 4.2 vs 30.7 7.1 kg chow and 11.5 1.3 kg polymeric formula). Villus height was increased in the jejunum, ileum and terminal ileum of resected animals compared with controls in animals fed with pig chow, polymeric formula and elemental formula. The animals that had a resection had a significant reduction in the transepithelial conductance (10.4 5.5 vs 25.4 6.5 mS/cm2) and 51Chromium-EDTA flux (2.8 1.9 vs 4.8 4.9 microL/h per cm2) compared with the controls. CONCLUSIONS: A complex diet was found to be superior to an elemental diet in terms of the morphological and functional features of adaptation following massive small bowel resection. |
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Authors:
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Julie E Bines; Russell G Taylor; Frances Justice; Monique C J Paris; Magdy Sourial; Eva Nagy; Sarah Emselle; Anthony G Catto-Smith; Peter J Fuller |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of gastroenterology and hepatology Volume: 17 ISSN: 0815-9319 ISO Abbreviation: J. Gastroenterol. Hepatol. Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-11-27 Completed Date: 2003-03-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8607909 Medline TA: J Gastroenterol Hepatol Country: Australia |
Other Details:
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Languages: eng Pagination: 1170-9 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Blackwell Publishing Asia Pty Ltd |
Affiliation:
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Department of Gastroenterology and Clinical Nutrition, Royal Children's Hospital, Parkville, Victoria, Australia. bines@cryptic.rch.unimelb.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological* Animals Case-Control Studies Female Food, Formulated* Ileum / metabolism, surgery Intestinal Mucosa / physiology* Intestine, Small / metabolism, surgery* Jejunum / metabolism Swine Weight Gain |
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