| Influence of dichloroacetate on pulmonary gas exchange and ventilation during incremental exercise in healthy humans. | |
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MedLine Citation:
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PMID: 19615473 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We hypothesised that dichloroacetate (DCA) would reduce blood lactate accumulation, pulmonary carbon dioxide output (.V(CO2)) and ventilation (.V(E)) at sub-maximal work rates, and improve exercise tolerance during incremental exercise in healthy humans. Nine males (mean+/-SD, age 27+/-4 years) completed, in random order, two ramp incremental cycle ergometer tests to the limit of tolerance following the intravenous infusion of DCA (75 mg/kg body mass in 80 ml saline) or an equivalent volume of saline (as placebo). Relative to control, blood [lactate] was significantly reduced by DCA immediately before exercise (CON: 0.7+/-0.2 vs. DCA: 0.5+/-0.2mM; P<0.05) and throughout exercise until 630s (P<0.05). Blood [HCO(3)(-)] was significantly higher in the DCA condition from 360s until 720s of exercise (P<0.05). .V(CO2) and .V(E) were both lower throughout exercise in the DCA condition, with the differences reaching significance at 90 and 180s for .V(CO2) (P<0.05) and at 90, 180, 450, 540, 630, and 810s for .V(E) (P<0.05). Exercise tolerance was not significantly altered (CON: 1029+/-109 vs. DCA: 1045+/-101s). Infusion of DCA resulted in reductions in blood [lactate], .V(CO2) and .V(E) during sub-maximal incremental exercise, consistent with the existence of a link between the bicarbonate buffering of metabolic acidosis and increased CO(2) output. However, the reduced blood lactate accumulation during sub-maximal exercise with DCA did not enhance exercise tolerance. |
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Authors:
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Daryl P Wilkerson; Iain T Campbell; Jamie R Blackwell; Nicolas J Berger; Andrew M Jones |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2009-07-15 |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: 168 ISSN: 1878-1519 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-09-02 Completed Date: 2009-11-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 224-9 Citation Subset: IM |
Affiliation:
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School of Sport and Health Sciences, St. Luke's Campus, University of Exeter, Exeter, Devon, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bicarbonates / blood Dichloroacetate / pharmacology* Energy Metabolism Exercise / physiology* Exercise Tolerance Heart Rate / drug effects Humans Lactic Acid / blood Male Oxygen Consumption / drug effects Physical Exertion / drug effects Pulmonary Gas Exchange / drug effects* Pulmonary Ventilation / drug effects* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Bicarbonates; 13425-80-4/Dichloroacetate; 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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