Document Detail

Influence of diabetes on manifestations and treatment outcome of pulmonary TB patients.
MedLine Citation:
PMID:  16466041     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To understand the influence of diabetes on the clinical and bacteriological aspects and treatment outcome of pulmonary tuberculosis (PTB) patients. SETTING AND DESIGN: Records of 692 consecutive smear-positive PTB patients admitted to a referral hospital in Riyadh, Saudi Arabia, were reviewed retrospectively. The characteristics of 187 patients with diabetes mellitus (PTB-DM group) were compared to 505 patients without DM (PTB group). RESULTS: In the PTB-DM group, 65.2% of the patients had numerous acid-fast bacilli (AFB) on sputum smear examination compared to 54.1% in the control group (P = 0.008). Among new cases, PTB-DM patients had a lower prevalence of resistance to any anti-tuberculosis drug (6.4% vs. 16.0%, P = 0.007) and achieved higher sputum conversion rates at the end of 3 months of treatment (98.9% vs. 94.7%, P = 0.013). Favourable outcomes (cured/treatment completed), failure, death and default were comparable in both groups (P = 0.7005). CONCLUSIONS: PTB-DM patients have a higher pre-treatment bacillary load, a lower prevalence of anti-tuberculosis drug resistance and achieve slightly higher sputum conversion by the end of 3 months of treatment compared to non-diabetic patients. The association of diabetes does not alter the final treatment outcome among PTB patients.
R Singla; N Khan; N Al-Sharif; M O Ai-Sayegh; M A Shaikh; M M Osman
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease     Volume:  10     ISSN:  1027-3719     ISO Abbreviation:  Int. J. Tuberc. Lung Dis.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-02-09     Completed Date:  2006-05-16     Revised Date:  2006-06-12    
Medline Journal Info:
Nlm Unique ID:  9706389     Medline TA:  Int J Tuberc Lung Dis     Country:  France    
Other Details:
Languages:  eng     Pagination:  74-9     Citation Subset:  IM    
Department of Tuberculosis and Chest Diseases, Lala Ram Sarup Institute of Tuberculosis and Respiratory Diseases, Sri Aurobindo Marg, New Delhi, India.
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MeSH Terms
Antitubercular Agents / therapeutic use
Child, Preschool
Diabetes Complications*
Drug Resistance, Bacterial
Middle Aged
Mycobacterium tuberculosis / drug effects,  isolation & purification
Sputum / microbiology
Treatment Outcome
Tuberculosis, Pulmonary / complications,  drug therapy*,  microbiology
Reg. No./Substance:
0/Antitubercular Agents

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