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Influence of diabetes on homocysteine-lowering therapy in chronic hemodialysis patients.
MedLine Citation:
PMID:  21439275     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: The effect of homocysteine (Hcy)-lowering therapy may be different in hemodialysis (HD) patients with and without diabetes mellitus (DM). METHODS: Stable HD patients with uremia were administered folic acid and vitamin B for 3months. The impact of treatment was compared in patients with and without DM. RESULTS: A total of 61 patients (31 men and 30 women) aged 56±13 y completed the study. Among these, 44 patients (72%) did not have DM and 17 (28%) had DM. At baseline, total Hcy and high-sensitivity C-reactive protein (hsCRP) levels were similar. After treatment, the levels of total Hcy and hsCRP were significantly decreased in the nondiabetic group (total Hcy level decreased from 33.63±14.13μmol/l to 18.94±8.46μmol/l, p<0.001; hsCRP level decreased from 0.58mg/dl [range, 0.21-1.05mg/dl] to 0.22mg/dl [range, 0.11-0.53mg/dl], p<0.001) but not in the diabetic group (total Hcy level decreased from 34.97±17.12μmol/l to 29.53±11.36μmol/l, p=0.057; hsCRP level decreased from 0.80mg/dl [range, 0.24-1.47mg/dl] to 0.49mg/dl [range, 0.45-0.98mg/dl], p=0.28). Serial monitoring of total Hcy level showed a more sustained effect of therapy on patients without DM. CONCLUSION: Folic acid and vitamin B administration significantly lower total Hcy and hsCRP levels in HD patients without DM but not in those with DM.
Authors:
Kuo-Cheng Lu; Wen-Ya Ma; Chun-Chi Chen; Kuo-Chin Hung; Hsiao-Shuang Chen; Chia-Chao Wu; Tzu-Yuan Chang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-22
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  -     ISSN:  1873-3492     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2010. Published by Elsevier B.V.
Affiliation:
Department of Medicine, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan.
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