| Influence of dexamethasone on growth and development of rat fetuses: changes in nucleic acids and protein content. | |
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MedLine Citation:
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PMID: 6187564 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pregnant rats were treated with dexamethasone in drinking water (10 micrograms/ml) from the 15th to the 22nd day of pregnancy. Dexamethasone significantly reduced the weight of rat fetuses and concentration of DNA, RNA and proteins in fetal adrenal glands, liver, placenta, brain, kidneys, heart, lung, testes and pituitary from the 17th to the 22nd day of pregnancy. These data show that dexamethasone given to pregnant rat may lead to potentially deleterious effects on fetal rat development. |
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Authors:
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R Klepac |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Endokrinologie Volume: 80 ISSN: 0013-7251 ISO Abbreviation: Endokrinologie Publication Date: 1982 Nov |
Date Detail:
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Created Date: 1983-05-27 Completed Date: 1983-05-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370675 Medline TA: Endokrinologie Country: GERMANY, EAST |
Other Details:
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Languages: eng Pagination: 311-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight / drug effects DNA / metabolism* Dexamethasone / pharmacology* Female Fetus / physiology* Growth / drug effects Maternal-Fetal Exchange Organ Size / drug effects Pregnancy Proteins / metabolism* RNA / metabolism* Rats Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Proteins; 50-02-2/Dexamethasone; 63231-63-0/RNA; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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