| Influence of detergent aerosol on lung microvascular permeability. | |
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MedLine Citation:
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PMID: 8482639 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Noncardiogenic edema fluid often contains high levels of plasma proteins, which may inhibit the function of the lung surfactant complex and thus decrease interstitial hydrostatic pressures. We questioned whether, in the awake and standing animal, displacement of the alveolar surface lining would alter the permeability of the thin and sparsely supported pulmonary capillaries. Sheep prepared with lung lymph fistulae were given an aerosolized detergent (Det) to displace the lung surfactant complex. After the sheep were given Det, protein flux was significantly increased (P < 0.05). To validate the suggested permeability increase, pulmonary vein occluders were surgically implanted and experiments repeated with pulmonary arterial pressures elevated 10 mmHg above baseline. After 2 h of elevated pulmonary arterial pressure, lung lymph increased fivefold. At this time, lymph-to-plasma total protein concentration ratios for air and saline-plus-ethanol vehicle were significantly lower (P < 0.01) than baseline ratios (0.26 +/- 0.06 and 0.34 +/- 0.07, respectively). No significant difference could be shown in lymph-to-plasma ratios after the sheep were given Det. We conclude that disruption of the alveolar lining can cause a detectable increase in protein flux due, in part, to an increase in microvascular permeability. |
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Authors:
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C Z Wang; R E Barrow; C S Cox; S F Yang; D N Herndon |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 74 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1993 Mar |
Date Detail:
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Created Date: 1993-06-01 Completed Date: 1993-06-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1016-23 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of Texas Medical Branch, Galveston 77550. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aerosols Animals Blood Gas Analysis Blood Pressure / physiology Blood Proteins / metabolism Capillary Permeability / drug effects* Detergents / administration & dosage, pharmacology* Extravascular Lung Water / metabolism Female Lung / metabolism* Lymph / drug effects Organ Size / physiology Pulmonary Circulation / drug effects Pulmonary Edema / physiopathology Pulmonary Veins / drug effects Sheep Surface Tension |
| Chemical | |
Reg. No./Substance:
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0/Aerosols; 0/Blood Proteins; 0/Detergents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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