| Influence of dendrimer generation and polyethylene glycol length on the biodistribution of PEGylated dendrimers. | |
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MedLine Citation:
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PMID: 19761822 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Dendrimers are a potential drug carrier. Because modification with polyethylene glycol (PEG) is known to improve the blood retention, PEGylated dendrimers have been studied as a useful drug carrier. In this study, three types of PEGylated L-lysine-bearing polyamidoamine dendrimers (PEG2k-Lys-PAMAM (G4), PEG5k-Lys-PAMAM (G4), PEG2k-Lys-PAMAM (G5)) were synthesized, which are composed of a dendrimer of different generations (generations 4 and 5) and PEG chains with different molecular weights (2k and 5k). An acetylated L-lysine-bearing dendrimer was also synthesized as a non-PEGylated dendrimer. Bifunctional diethylenetriaminepentaacetic acid (pSCN-benzyl-DTPA) was bound to the epsilon -amino group of lysine in a dendrimer, to be labeled with radioactive indium-111. These PEGylayed dendrimers showed longer blood retention and lower accumulation in other normal organs such as the kidneys than the non-PEGylated dendrimer. The PEGylated dendrimers with the higher generation and the longer PEG led the greater blood retention. |
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Authors:
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Chie Kojima; Celeste Regino; Yasuhito Umeda; Hisataka Kobayashi; Kenji Kono |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-15 |
Journal Detail:
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Title: International journal of pharmaceutics Volume: 383 ISSN: 1873-3476 ISO Abbreviation: Int J Pharm Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-11-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804127 Medline TA: Int J Pharm Country: Netherlands |
Other Details:
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Languages: eng Pagination: 293-6 Citation Subset: IM |
Affiliation:
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Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, Osaka, Japan. c-kojima@21c.osakafu-u.ac.jp |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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