| Influence of corticotropin-releasing factor on pancreatic and islet blood flow in different regions of the rat pancreas. | |
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MedLine Citation:
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PMID: 7657051 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Corticotropin-releasing factor (CRF) has previously been shown to selectively dilate the mesenteric vascular bed, without affecting other vascular beds. Pancreatic blood flow and islet blood flow were therefore measured separately with a microsphere technique in the two regions of the rat pancreas perfused by the superior mesenteric artery (SMA) or celiac artery (CA) respectively. Intravenous infusion of CRF (0.25 microgram/kg b.w./min) caused an increase in both whole pancreatic blood flow and islet blood flow in the region of the pancreas perfused by the SMA. The fraction of whole pancreatic blood flow diverted through the islets in this part of the pancreas was, however, unaffected by CRF infusion (approximately 10%). CRF did not change either pancreatic or islet blood flow in the CA-perfused part of the pancreas, and did not affect the release of insulin. |
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Authors:
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P O Carlsson; M Stridsberg; L Jansson |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Digestion Volume: 56 ISSN: 0012-2823 ISO Abbreviation: Digestion Publication Date: 1995 |
Date Detail:
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Created Date: 1995-09-29 Completed Date: 1995-09-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0150472 Medline TA: Digestion Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 242-5 Citation Subset: IM |
Affiliation:
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Department of Medical Cell Biology, University Hospital, Uppsala, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / metabolism Celiac Artery Corticotropin-Releasing Hormone / pharmacology* Insulin / metabolism Islets of Langerhans / blood supply* Male Mesenteric Artery, Superior Microspheres Pancreas / blood supply* Rats Rats, Sprague-Dawley Regional Blood Flow / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 11061-68-0/Insulin; 9015-71-8/Corticotropin-Releasing Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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