Document Detail


Influence of coronary occlusion on pulmonary vascular resistance in anesthetized dogs.
MedLine Citation:
PMID:  831428     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of occlusion of the left anterior descending coronary artery on pulmonary hemodynamics and calculated pulmonary vascular resistance were measured in 17 open chest dogs anesthetized with chloralose. Coronary occlusion was associated with a slight but insignificant increase in mean pulmonary arterial pressure together with a significant elevation in mean left atrial pressure (P less than 0.01) and a significant reduction in mean pulmonary flow (P less than 0.01). Calculated pulmonary vascular resistance was significantly reduced during occlusion (P less than 0.01). The reduction in resistance was associated with elevated mean left atrial pressure and therefore reflected passive distension of pulmonary vessels secondary to suppressed left ventricular function. In contrast, coronary occlusion after vagotomy was not associated with a significant reduction in pulmonary vascular resistance, and in six experiments the decrease in resistance was converted to an increase. It is concluded that, before vagotomy, pulmonary hemodynamics during coronary occlusion are primarily affected through passive vessel distension whereas, after vagotomy tonic suppression of sympathetic activity is interrupted, thereby allowing enhancement of sympathetic vasoconstrictor activity to the pulmonary vascular bed and producing an increase in calculated resistance.
Authors:
J B Pace; R M Gunnar
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of cardiology     Volume:  39     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1977 Jan 
Date Detail:
Created Date:  1977-02-26     Completed Date:  1977-02-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  60-5     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Flow Velocity
Blood Pressure
Blood Pressure Determination / instrumentation
Coronary Disease / physiopathology*
Disease Models, Animal
Dogs
Female
Hemodynamics
Male
Pulmonary Circulation*
Vagotomy
Vascular Resistance*
Vasomotor System

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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