| Influence of coronary collateral flow on coronary diagnostic parameters: an in vitro study. | |
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MedLine Citation:
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PMID: 19775695 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Functional severity of coronary stenosis is often assessed using diagnostic parameters. These parameters are evaluated from the combined pressure and/or flow measurements taken at the site of the stenosis. However, when there are functional collaterals operating downstream to the stenosis, the coronary flow-rate increases, and the pressure in the stenosed artery is altered. This effect of downstream collaterals on different diagnostic parameters is studied using a physiological representative in vitro coronary flow-loop. The three diagnostic parameters tested are fractional flow reserve (FFR), lesion flow coefficient (LFC), and pressure drop coefficient (CDP). The latter two were discussed in recent publications by our group (Banerjee et al., 2007, 2008, 2009). They are evaluated for three different severities of stenosis and tested for possible misinterpretation in the presence of variable collateral flows. Pressure and flow are measured with and without downstream collaterals. The diagnostic parameters are then calculated from these readings. In the case of intermediate stenosis (80% area blockage), FFR and LFC increased from 0.74 to 0.77 and 0.58 to 0.62, respectively, for no collateral to fully developed collateral flow. Also, CDP decreased from 47 to 42 for no collateral to fully developed collateral flow. These changes in diagnostic parameters might lead to erroneous postponement of coronary intervention. Thus, variability in diagnostic parameters for the same stenosis might lead to misinterpretation of stenosis severity in the presence of operating downstream collaterals. |
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Authors:
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Srikara Viswanath Peelukhana; Lloyd H Back; Rupak K Banerjee |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-22 |
Journal Detail:
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Title: Journal of biomechanics Volume: 42 ISSN: 1873-2380 ISO Abbreviation: J Biomech Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2010-01-28 Completed Date: 2010-04-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0157375 Medline TA: J Biomech Country: United States |
Other Details:
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Languages: eng Pagination: 2753-9 Citation Subset: IM |
Affiliation:
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Department of Mechanical Engineering, University of Cincinnati, Cincinnati, OH 45221, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biomimetics
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methods Blood Flow Velocity* Blood Pressure* Collateral Circulation* Coronary Circulation* Coronary Stenosis / diagnosis*, physiopathology* Coronary Vessels / physiopathology* Humans Models, Cardiovascular Reproducibility of Results Sensitivity and Specificity |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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