Document Detail

Influence of copper and zinc on urethan-induced adenoma development in mice.
MedLine Citation:
PMID:  3240718     Owner:  NLM     Status:  MEDLINE    
Female Swiss mice were exposed to zinc chloride (0 to 500 ug/mL) or copper sulfate (0 to 200 ug/mL) in their drinking water for 15 weeks. After 3 weeks of the exposure period, the mice were administered urethan (1.5 mg/g) intraperitoneally. Urethan-induced pulmonary adenoma formation was evaluated 12 weeks later. Zinc exposure increased the number of adenomas produced but reduced the mean tumor diameter in the intermediate treatment groups, 50 and 200 ug/mL. Exposure to copper had no effect on tumor size or on tumor number. Weight gains in the mice were not affected by copper or zinc treatment, although a dose-dependent reduction in water consumption was observed with copper. Water consumption in mice exposed to zinc was elevated in one treatment group (50 ug/mL). Urethan-induced sleeping times, which reflect the rate of urethan excretion, were prolonged by zinc exposure but were unaffected by copper exposure. This finding suggests that zinc exposure impairs the elimination of urethan and enhances its carcinogenic activity, which is manifested by increased tumor formation.
B R Blakley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Drug-nutrient interactions     Volume:  5     ISSN:  0272-3530     ISO Abbreviation:  Drug Nutr Interact     Publication Date:  1988  
Date Detail:
Created Date:  1989-05-18     Completed Date:  1989-05-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8307198     Medline TA:  Drug Nutr Interact     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  395-401     Citation Subset:  IM    
Department of Veterinary Physiological Sciences, University of Saskatchewan, Saskatoon, Canada.
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MeSH Terms
Adenoma / chemically induced,  metabolism*
Administration, Oral
Copper / pharmacology*
Lung Neoplasms / chemically induced,  metabolism*
Sleep / drug effects
Urethane / adverse effects,  metabolism
Zinc / pharmacology*
Reg. No./Substance:
51-79-6/Urethane; 7440-50-8/Copper; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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