Document Detail


Influence of copper on early development: prenatal and postnatal considerations.
MedLine Citation:
PMID:  20232410     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Copper (Cu) is an essential nutrient whose requirement is increased during pregnancy and lactation. These represent times of critical growth and development, and the fetus and neonate are particularly vulnerable to deficiencies of this nutrient. Genetic mutations that predispose the offspring to inadequate stores of Cu can be life threatening as is observed in children with Menkes disease. During the last decade, severe Cu deficiency, once thought to be a rare condition, has been reported in the literature at an increasing frequency. Secondary Cu deficiencies can be induced by a variety of ways such as excessive zinc or iron intake, certain drugs, and bariatric surgery. Premature and low birth weight infants can be born with low Cu stores. A number of mechanisms can contribute to the teratogenicity of Cu including decreased activity of select cuproenzymes, increased oxidative stress, decreased nitric oxide availability, altered iron metabolism, abnormal extracellular matrix protein crosslinking, decreased angiogenesis and altered cell signaling among others. The brain, heart, and vessels as well as tissues such as lung, skin and hair, and systems including the skeletal, immune, and blood systems, are negatively affected by suboptimal Cu during development. Additionally, persistent structural, biochemical, and functional adverse effects in the offspring are noted even when Cu supplementation is initiated after birth, supporting the concept that adequate Cu nutriture during pregnancy and lactation is critical for normal development. Although Cu-containing IUDs are an effective method for increasing intrauterine Cu concentrations and for reducing the risk of pregnancy, high amounts of dietary Cu are not thought to represent a direct developmental risk.
Authors:
Janet Y Uriu-Adams; Rachel E Scherr; Louise Lanoue; Carl L Keen
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  BioFactors (Oxford, England)     Volume:  36     ISSN:  1872-8081     ISO Abbreviation:  Biofactors     Publication Date:    2010 Mar-Apr
Date Detail:
Created Date:  2010-04-14     Completed Date:  2010-06-28     Revised Date:  2010-12-20    
Medline Journal Info:
Nlm Unique ID:  8807441     Medline TA:  Biofactors     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  136-52     Citation Subset:  IM    
Affiliation:
Department of Nutrition, University of California, Davis, Davis, CA 95616, USA. jyuriuadams@ucdavis.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Copper / deficiency,  metabolism,  physiology*
Female
Humans
Nitric Oxide / metabolism
Pregnancy
Prenatal Nutritional Physiological Phenomena / physiology
Grant Support
ID/Acronym/Agency:
HD-26777/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
10102-43-9/Nitric Oxide; 7440-50-8/Copper

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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