Document Detail

Influence of contrast media on the response of rat renal arteries to endothelin and nitric oxide: influence of contrast media.
MedLine Citation:
PMID:  9647448     Owner:  NLM     Status:  MEDLINE    
RATIONALE AND OBJECTIVES: Contrast media (CM) such as diatrizoate meglumine (DTZ) or iohexol can cause renal vasoconstriction in vivo, and this may initiate CM-induced nephropathy. Endothelin-1 (ET-1), a vasoconstrictor, and nitric oxide, a vasodilator, are key modulators of renal circulation. We tested the hypothesis that CM enhances arterial responses to ET-1, or diminishes responses to nitric oxide. METHODS: A video dimension analyzer continuously recorded changes in diameter of isolated, pressurized rat interlobar renal arteries (200-400 microm diameter) superfused with combinations of CM, ET-1, nitric oxide, and other vasoactive agents. RESULTS: Superfusion of arteries with 3.3% DTZ, but not with 3.3% iohexol, enhanced their sensitivity to ET-1 by approximately twofold, as assessed by shifts in concentration-response curves. Both DTZ and iohexol decreased the sensitivity of arteries to nitric oxide by approximately threefold. Neither DTZ nor iohexol affected arterial sensitivity to other vasoconstrictors (phenylephrine, potassium) or vasodilators (forskolin, diltiazem). CONCLUSIONS: Diatrizoate meglumine and iohexol may induce or augment renal vasoconstriction in part by causing selective alterations in arterial sensitivity to ET-1 and to nitric oxide.
M E Murphy; M E Tublin; S Li
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Investigative radiology     Volume:  33     ISSN:  0020-9996     ISO Abbreviation:  Invest Radiol     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-09-23     Completed Date:  1998-09-23     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0045377     Medline TA:  Invest Radiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  356-65     Citation Subset:  IM    
Department of Pharmacology, The Albany Medical Center, New York 12208, USA.
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MeSH Terms
Analysis of Variance
Angiography / instrumentation
Contrast Media / pharmacology*
Diatrizoate Meglumine / pharmacology
Dose-Response Relationship, Drug
Endothelin-1 / pharmacology*
Iohexol / pharmacology
Nitric Oxide / pharmacology*
Rats, Sprague-Dawley
Renal Artery / drug effects*,  physiology
Sensitivity and Specificity
Reg. No./Substance:
0/Contrast Media; 0/Endothelin-1; 10102-43-9/Nitric Oxide; 131-49-7/Diatrizoate Meglumine; 66108-95-0/Iohexol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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