Document Detail

Influence of congenital heart disease on survival in children with congenital diaphragmatic hernia.
MedLine Citation:
PMID:  12091847     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We sought to assess outcome in patients with CDH and HD to determine if LHR is also predictive of outcome in this subset of patients. STUDY DESIGN: We carried out a retrospective review (April 1996-October 2000) of patients with isolated CDH (n = 143, 82.2%) and patients with HD (n = 31, 17.8%) to determine the incidence of additional anomalies, survival to term, CDH repair, cardiac repair, and survival to discharge. Survival based on LHR was analyzed in a subset of fetuses. RESULTS: The risk of death from birth to last follow-up was 2.9 times higher for patients with CDH plus HD than for patients with CDH alone (P <.0001). Of 11 patients with CDH plus HD who had CDH repair (5 of whom also had HD repair), 5 survived. All 10 patients with an LHR <1.2 died; 3 of 6 with an LHR >1.2 survived (Fisher exact test, P =.04). CONCLUSION: Heart disease remains a significant risk factor for death in infants with CDH. The LHR helps predict survival in this high-risk group of patients.
Meryl S Cohen; Jack Rychik; David M Bush; Zhi-Yun Tian; Lori J Howell; N Scott Adzick; Alan W Flake; Mark P Johnson; Thomas L Spray; Timothy M Crombleholme
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  141     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-01     Completed Date:  2002-08-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  25-30     Citation Subset:  AIM; IM    
Cardiac Center and The Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.
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MeSH Terms
Abnormalities, Multiple / mortality*
Heart Defects, Congenital*
Hernia, Diaphragmatic / congenital*,  mortality*,  ultrasonography
Infant, Newborn
Lung / pathology
Pennsylvania / epidemiology
Proportional Hazards Models
Retrospective Studies
Survival Rate
Ultrasonography, Prenatal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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