Document Detail


Influence of commonly employed resistance exercise protocols on circulating IL-6 and indices of insulin sensitivity.
MedLine Citation:
PMID:  20168253     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this project was to examine the influence of resistance exercise (RE) intensities, resulting in different total volume loads on circulating interleukin-6 (IL-6), insulin and glucose response (IGR) to a carbohydrate feeding (CHO), and whether RE-induced IL-6 was associated with postexercise IGR. Fourteen men (21.7 +/- 1.7 years, 83 +/- 14.2 kg), performed 2 RE sessions (low-intensity resulting in high volume [65% 1-repetition maximum (1RM)], LO; high intensity resulting in low volume [85% 1RM], HI); and a nonexercise control trial (CON). Resistance exercise included 3 sets (LO = 12 reps, 12 reps, and failure; HI = 8 reps, 8 reps, and failure) of 8 exercises. Blood was obtained pre- (PR) and post (PO) exercise, and 6 hours postexercise (6H). Twenty-three hours after RE or CON, participants consumed 100 g dextrose (CHO) beverage. Blood was collected before (0 minutes) and 60 minutes after CHO (n = 6, phase 1) or every 30 minutes for a 2-hour oral glucose tolerance test (n = 8; phase 2). Circulating IL-6, insulin, and glucose were analyzed via enzyme-linked immunosorbent assay, radioimmunoassay, and enzymatic methods, respectively. Total volume load was higher in LO (17,729 +/- 1,466 kg) compared with HI (13,160 +/- 1,097 kg; p < 0.001). Postexercise IL-6 was elevated (p = 0.003) in LO and HI compared with CON (7.4 +/- 1.3, 5.2 +/- 0.7, and 2.5 +/- 0.7 pg.mL, respectively), with LO IL-6 greater than HI. Areas under the curve for glucose (p = 0.081; CON: 741 +/- 46, LO: 690 +/- 28, and HI: 660 +/- 21 mM.min) and insulin (p = 0.075; CON: 6,818 +/- 1,018, LO: 5,056 +/- 869, and HI: 5,405 +/- 1,076 microIU.mL) were not different among trials (n = 8). When 0- and 60-minute values were compared (n = 14), insulin was lower at 60 minutes in LO and HI compared with CON (55 + 9.1, 83 +/- 13, 105 +/- 13 microIU.mL, respectively) with LO insulin being lower than HI (p < 0.001). No relationship was observed between PO IL-6 and IGR, but PR IL-6 was negatively related to both PR (r = -0.043, p < 0.05) and 60 minutes (r = -0.59, p < 0.01) glucose (n = 14). These results indicate that TVL contributes to RE-induced IL-6 release and that TVL may be more important than RE intensity when improvements in glucose tolerance or IS are the goal.
Authors:
Melody D Phillips; Joel B Mitchell; Lauren M Currie-Elolf; Robert C Yellott; Kimberly A Hubing
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of strength and conditioning research / National Strength & Conditioning Association     Volume:  24     ISSN:  1533-4287     ISO Abbreviation:  J Strength Cond Res     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-08     Completed Date:  2010-07-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9415084     Medline TA:  J Strength Cond Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1091-101     Citation Subset:  IM    
Affiliation:
Exercise Physiology Laboratory, Department of Kinesiology, Texas Christian University, Fort Worth, Texas, USA. m.phillips@tcu.edu
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Anthropometry
Athletic Performance / physiology
Blood Glucose / analysis
Case-Control Studies
Dietary Carbohydrates / administration & dosage*
Energy Metabolism / physiology*
Enzyme-Linked Immunosorbent Assay
Glucose Tolerance Test
Humans
Insulin / blood*,  metabolism
Insulin Resistance
Interleukin-6 / blood*,  metabolism
Male
Oxygen Consumption / physiology
Physical Endurance / physiology
Probability
Reference Values
Resistance Training / methods*
Risk Factors
Weight Lifting / physiology
Young Adult
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Dietary Carbohydrates; 0/Interleukin-6; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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