| Influence of combined C-peptide and insulin administration on renal function and metabolic control in diabetes type 1. | |
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MedLine Citation:
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PMID: 8408474 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The possible influence of C-peptide on renal function and metabolic control in patients with type 1 diabetes was examined in a double blind, randomized study. Nine patients received insulin and equimolar amounts of biosynthetic human C-peptide for 1 month (group 1), and nine were given insulin only (group 2). C-Peptide levels in plasma ranged from 0.3-2.6 nmol/L in group 1 during the study, whereas group 2 had undetectable levels. The urinary excretion of albumin in group 1 was 21 +/- 6 micrograms/min before the study and decreased by 40% and 55% after 2 and 4 weeks, respectively (P < 0.05). No change was seen in group 2. The glomerular filtration rate fell by 6% after 2 and 4 weeks (P < 0.05) in group 1, whereas no change was observed in group 2. Fluorescein leakage across the blood-retinal barrier decreased by 30% in group 1 (P < 0.05) and was unaltered in group 2. Hemoglobin-A1c and fructosamine values decreased by 9-16% in group 1 (P < 0.05), but not in group 2. The findings suggest that administration of C-peptide plus insulin, compared to insulin alone, to type 1 diabetic patients may reduce glomerular permeability and improve metabolic control. |
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Authors:
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B L Johansson; A Kernell; S Sjöberg; J Wahren |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 77 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 1993 Oct |
Date Detail:
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Created Date: 1993-11-12 Completed Date: 1993-11-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 976-81 Citation Subset: AIM; IM |
Affiliation:
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Department of Clinical Physiology, Karolinska Hospital, Stockholm, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Albuminuria Blood Glucose / drug effects Blood-Retinal Barrier / drug effects C-Peptide / administration & dosage, pharmacology, therapeutic use* Diabetes Mellitus, Type 1 / drug therapy*, physiopathology Double-Blind Method Female Fluorescein Fluoresceins / pharmacokinetics Fructosamine Glomerular Filtration Rate / drug effects Glucagon / blood Growth Hormone / blood Hemoglobin A, Glycosylated / analysis Hexosamines / blood Humans Insulin / administration & dosage, pharmacology, therapeutic use* Insulin Infusion Systems Kidney / drug effects*, physiopathology Male Norepinephrine / blood Pilot Projects |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/C-Peptide; 0/Fluoresceins; 0/Hemoglobin A, Glycosylated; 0/Hexosamines; 11061-68-0/Insulin; 2321-07-5/Fluorescein; 4429-04-3/Fructosamine; 51-41-2/Norepinephrine; 9002-72-6/Growth Hormone; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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