| Influence of colforsin daropate hydrochloride on internal mammary artery grafts. | |
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MedLine Citation:
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PMID: 11954952 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of colforsin daropate hydrochloride (colforsin), a water-soluble forskolin derivative, on blood flow in internal mammary artery (IMA) grafts was evaluated in a prospective randomized study of 26 patients undergoing coronary artery bypass grafting. Patients were randomized to receive either colforsin treatment (colforsin; n=14) or no colforsin treatment (control; n=14). Administration of colforsin (0.5mg x kg(-1) min(-1)) was started after induction of anesthesia and was continued for 6 h. IMA blood flow and hemodynamic measurements were assessed perioperatively. During cardiopoulmonary bypass (CPB), perfusion flow was adjusted to 2.5 L/m2 and IMA free blood flow was measured. IMA blood flow was also measured 1 h after CPB by an ultrasonic flow meter. Systemic vascular resistance was significantly lower in the colforsin group during and after CPB. IMA blood flow was significantly greater in the colforsin group than in the control group during (44 +/- 2 vs 33 +/- 3 ml min-1 x m(-2), p=0.02) and after CPB (38 +/- 6 vs 20 +/- 3ml x min(-1) m(-2), p=0.01). IMA blood flow 1 h after CPB correlated inversely with concurrent systemic vascular resistance (r=-0.61, p=0.001). Intraoperative administration of colforsin daropate hydrochloride caused potent vasodilation, resulting in an increase in IMA blood flow. The results indicate that the regimen can be used perioperatively in patients undergoing coronary artery bypass grafting. |
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Authors:
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Nobuhiko Hayashida; Hideki Teshima; Eiki Tayama; Shingo Chihara; Naofumi Enomoto; Takemi Kawara; Shigeaki Aoyagi |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 66 ISSN: 1346-9843 ISO Abbreviation: Circ. J. Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-04-16 Completed Date: 2002-10-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 372-6 Citation Subset: IM |
Affiliation:
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Department of Surgery, Kurume University, Fukuoka, Japan. nobuhiko@med.kurume-u.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure
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drug effects Female Forskolin / analogs & derivatives*, therapeutic use* Heart Rate / drug effects Hemodynamics / drug effects* Humans Internal Mammary-Coronary Artery Anastomosis* / methods Lactates / blood Male Middle Aged Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 0/colforsin daropate; 66428-89-5/Forskolin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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