| Influence of cold stress on neuropeptide Y and sympathetic neurotransmission. | |
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MedLine Citation:
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PMID: 15992963 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chronic cold stress of rats (4 degrees C; 1-3 weeks) induced a marked increase in gene expression (adrenal medulla; superior cervical ganglia), tissue content (mesenteric arterial bed) and nerve stimulation-induced overflow of NPY-immunoreactivity (NPYir) from the perfused mesenteric arterial bed. In contrast increased NPY neurotransmission was offset by an apparent decrease in the evoked overflow of norepinephrine (NE) due to a presumed deactivation of NE by nitric oxide (NO), despite increased sympathetic nerve activity. The net effect of these offsetting system was no change in basal or the evoked increase in perfusion pressure (sympathetic tone). It is concluded that differences in NPY and NE transmission act as an important compensatory mechanism preventing dramatic changes in arterial pressure when sympathetic nerve activity is high during cold stress. |
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Authors:
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Songping Han; Xiaoli Chen; Chun-Lian Yang; Lillian Vickery; Yumei Wu; Linda Naes; Heather Macarthur; Thomas C Westfall |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2005-06-29 |
Journal Detail:
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Title: Peptides Volume: 26 ISSN: 0196-9781 ISO Abbreviation: Peptides Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-11-25 Completed Date: 2006-02-28 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: United States |
Other Details:
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Languages: eng Pagination: 2603-9 Citation Subset: IM |
Affiliation:
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Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St. Louis, MO 63104, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological* Animals Cold Temperature* Evoked Potentials Male Mesenteric Arteries / innervation, metabolism Neuropeptide Y / biosynthesis* RNA, Messenger / biosynthesis Rats Rats, Sprague-Dawley Stress, Physiological / metabolism* Sympathetic Nervous System / metabolism* Synaptic Transmission* |
| Grant Support | |
ID/Acronym/Agency:
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HL 60260/HL/NHLBI NIH HHS; HL 61836/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Neuropeptide Y; 0/RNA, Messenger |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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