| Influence of cilnidipine or nisoldipine on sympathetic activity in healthy male subjects. | |
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MedLine Citation:
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PMID: 18043999 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to investigate whether cilnidipine, an N- and L-type calcium channel blocker, and nisoldipine, an L-type calcium channel blocker, have different effects on sympathetic activity, using an identical group of healthy male subjects. Eight healthy men (22-28 years) were given 10 mg of cilnidipine or 10 mg of nisoldipine in a randomized crossover design. In each trial, in subjects without medication on day 1 (control) and with medication on day 2, we measured heart rate (HR), low frequency (LF)/high frequency (HF) of HR variability, and plasma noradrenaline (NA) in a resting supine position and during head-up tilt, and palmar sweating during a mental arithmetic test, before and at 1, 2, 4, 6, and 8 h after administration. Time-plasma concentration profiles of the two drugs were similar. Measurements in controls on the two days showed no significant difference in any of these parameters. Nisoldipine, but not cilnidipine, slightly increased HR and LF/HF at rest. Head-up tilt increased HR, LF/HF, and plasma NA. As evaluated with repeated-measures analysis of variance, head-up tilt induced a significant increase in LF/HF, but not HR or plasma NA, and the effect of cilnidipine was significantly less than that of nisoldipine (P = 0.017). Postural hypotension was not observed. There was no difference in mental arithmetic-induced sweating between the two drugs. Cilnidipine, but not nisoldipine, might have a weak inhibitory effect on reflex sympathetic activity. |
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Authors:
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Tsuyoshi Shiga; Yuichiro Yamada; Naoki Matsuda; Takanori Tanaka; Akinori Urae; Masayuki Hashiguchi; Nobuhisa Hagiwara; Hiroshi Kasanuki |
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Publication Detail:
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Type: Journal Article Date: 2007-11-26 |
Journal Detail:
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Title: Heart and vessels Volume: 22 ISSN: 0910-8327 ISO Abbreviation: Heart Vessels Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-11-28 Completed Date: 2008-06-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8511258 Medline TA: Heart Vessels Country: Japan |
Other Details:
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Languages: eng Pagination: 404-9 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Tokyo Women's Medical University, Tokyo, Japan. mshiga@hij.twmu.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Calcium Channel Blockers / pharmacology* Dihydropyridines / pharmacology* Heart Rate / drug effects* Humans Male Nisoldipine / pharmacology* Norepinephrine / blood Posture Sympathetic Nervous System / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 0/Dihydropyridines; 132203-70-4/cilnidipine; 51-41-2/Norepinephrine; 63675-72-9/Nisoldipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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