Document Detail

Influence of cigarette smoking on the outcome of coronary care unit admissions with chest pain.
MedLine Citation:
PMID:  1437954     Owner:  NLM     Status:  MEDLINE    
We studied the effect of current smoking habits in the period immediately before admission to hospital in 90 consecutive patients presenting with chest pain, 50 of whom were shown to have myocardial infarction. Urine cotinine/creatinine (cot/creat) ratio measured within 4 hours of admission was used as an objective marker of cigarette smoking in the preceding 18 hours. Fifty-seven patients had urine cot/creat ratios suggesting recent smoking, although four of these denied smoking. Patients with myocardial infarction had higher median cot/creat ratios (3.31 micrograms/mg, range 0-17.8) compared with patients with non-infarct chest pain (0.5 microgram/mg, range 0-37.2). Sixteen patients with cardiac rhythm disturbances following infarction had significantly higher cot/creat ratios than the 34 infarct patients without this complication (median and range 8.34 micrograms/mg; 0-17.8 V. 1.87 micrograms/mg; 0-16.4, P < 0.01). Tobacco use in the 24 hours before myocardial infarction may predispose to cardiac rhythm disturbance, irrespective of infarct size.
S Mallya; P M Calverley; I A MacFarlane; S Hughes; G Johnston; C van Heyningen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Postgraduate medical journal     Volume:  68     ISSN:  0032-5473     ISO Abbreviation:  Postgrad Med J     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-12-09     Completed Date:  1992-12-09     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  0234135     Medline TA:  Postgrad Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  562-5     Citation Subset:  IM    
Department of Medicine and Pathology, Aintree Hospitals, Liverpool, UK.
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MeSH Terms
Aged, 80 and over
Arrhythmias, Cardiac / etiology
Coronary Care Units
Cotinine / urine
Creatinine / urine
Middle Aged
Myocardial Infarction / etiology*,  urine
Prospective Studies
Smoking / adverse effects*,  urine
Reg. No./Substance:
486-56-6/Cotinine; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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