| Influence of chronic stellectomy on reactivity to serotonin in the dog external carotid bed. | |
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MedLine Citation:
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PMID: 4004413 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The influence of chronic stellectomy on external carotid flow responses to i.a. serotonin (5HT) was determined in dogs in which both stellate ganglia had been removed 1, 2, 4 or 8 weeks previously. The effect of this maneuver on carotid and heart rate responses to i.a. and i.v. norepinephrine (NE), respectively, was also assessed for comparison. Constrictor responses to NE in the carotid were moderately increased at 2 and 4 weeks, while its positive chronotropic effects were markedly augmented throughout the observation period. Dilator responses to 5HT increased at 4 and specially at 8 weeks after stellectomy. Results obtained with NE were considered compatible with supersensitivity induced by decentralization in the carotid and by denervation in the heart. Changes in carotid responses to 5HT were interpreted as being due to a prejunctional mechanism similar to that responsible for supersensitivity to NE. Differences in the time course of development of supersensitivity to both amines were attributed to masking of 5HT dilatation by NE released by the indoleamine at the time of increased sensitivity to constriction by the catecholamine. |
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Authors:
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M A Mena; H Vidrio; G Burkle |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives internationales de pharmacodynamie et de thérapie Volume: 273 ISSN: 0003-9780 ISO Abbreviation: Arch Int Pharmacodyn Ther Publication Date: 1985 Jan |
Date Detail:
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Created Date: 1985-07-12 Completed Date: 1985-07-12 Revised Date: 2012-01-12 |
Medline Journal Info:
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Nlm Unique ID: 0405353 Medline TA: Arch Int Pharmacodyn Ther Country: BELGIUM |
Other Details:
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Languages: eng Pagination: 110-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Carotid Artery, External / drug effects*, innervation Dogs Female Heart Rate / drug effects Male Norepinephrine / pharmacology Regional Blood Flow / drug effects Serotonin / pharmacology* Sympathectomy Vasoconstriction / drug effects* |
| Chemical | |
Reg. No./Substance:
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50-67-9/Serotonin; 51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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