Document Detail

Influence of chronic mild stress on the behavioural effects of acute tryptophan depletion induced by a gelatin-based mixture.
MedLine Citation:
PMID:  18797247     Owner:  NLM     Status:  MEDLINE    
Several types of stress can increase vulnerability to developing depression. This depression may be caused by the effects of stress on the serotonergic system, which may make the system more vulnerable. The aim of this experiment was to evaluate whether chronic mild stress (CMS) resulted in long-lasting vulnerability of the serotonergic system, reflected by stronger behavioural responses to a serotonergic challenge with acute tryptophan depletion (ATD) several weeks after the CMS had ended. Male Wistar rats were exposed to 3 weeks of CMS followed by a 2-week resting period. CMS resulted in blunted weight gain and lower sucrose consumption. After the resting period, rats were repeatedly treated with a gelatin-based protein-carbohydrate mixture, either with or without L-tryptophan, to acutely challenge the serotonergic system and the rats were tested in several tests of anxiety-related and depression-related behaviour and memory. CMS and ATD both influenced behaviour on some tests, but overall this CMS procedure did not result in increased sensitivity to ATD, as there were no CMSxATD interaction effects on behaviour. In conclusion, CMS did not result in long-lasting vulnerability of the serotonergic system, measured by the behavioural response to ATD several weeks after the CMS had ended.
Linda A W Jans; Arjan Blokland
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Behavioural pharmacology     Volume:  19     ISSN:  0955-8810     ISO Abbreviation:  Behav Pharmacol     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-17     Completed Date:  2009-01-23     Revised Date:  2009-07-07    
Medline Journal Info:
Nlm Unique ID:  9013016     Medline TA:  Behav Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  706-15     Citation Subset:  IM    
Department of Neuropsychology and Psychopharmacology, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands.
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MeSH Terms
Amino Acids / pharmacology
Anxiety / physiopathology
Appetitive Behavior / physiology
Arousal / physiology
Behavior, Animal / physiology*
Body Weight
Depression / physiopathology
Fear / physiology
Maze Learning / physiology
Mental Recall / physiology
Pattern Recognition, Visual / physiology
Serotonin / metabolism
Social Behavior
Stress, Psychological / physiopathology*
Taste / physiology
Tryptophan / deficiency*,  pharmacology,  physiology
Reg. No./Substance:
0/Amino Acids; 50-67-9/Serotonin; 73-22-3/Tryptophan

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