Document Detail


Influence of chronic hypoxia on salbutamol tissular concentrations and on respiratory resistance in anesthetized rabbits.
MedLine Citation:
PMID:  7952567     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Salbutamol is a potent beta 2-adrenoceptor agonist given to patients with bronchial asthma who are frequently hypoxemic. The aims of this study were to document the influence of chronic hypoxia on salbutamol tissue concentrations and on salbutamol effect on total respiratory resistance. To this purpose, salbutamol (60 micrograms/kg) was administered intravenously to four groups of six rabbits exposed to four experimental conditions: (1) control rabbits breathing air, (2) histamine-induced bronchoconstriction in rabbits breathing air, (3) animals with chronic hypoxia, (4) histamine-induced bronchoconstriction in animals with chronic hypoxia. The area under salbutamol plasma concentration time curve (0 to 45 min) was not affected by these experimental conditions. Compared with control rabbits breathing air, following histamine-induced bronchoconstriction, salbutamol concentrations rose by 40 to 50% in lung and heart (p < 0.05). Hypoxia did not affect salbutamol distribution in these organs; however, in hypoxic animals, histamine-induced bronchoconstriction increased salbutamol concentrations only in the heart (p < 0.05), without affecting those in the lung. Compared with rabbits breathing air and with histamine-induced bronchoconstriction, the effect of salbutamol was reduced in rabbits under chronic hypoxia and histamine-induced bronchoconstriction (p < 0.05). We conclude that chronic hypoxia reduces salbutamol effect on pulmonary resistance, possibly by decreasing salbutamol lung concentrations.
Authors:
S Perreault; C Saunier; C Duvivier; R Peslin; H Ong; P Du Souich
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  150     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1994-12-13     Completed Date:  1994-12-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1374-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Pharmacology, Faculty of Medicine, University of Montréal, Québec, Canada.
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MeSH Terms
Descriptor/Qualifier:
Airway Resistance / drug effects*
Albuterol / pharmacokinetics*,  pharmacology*
Animals
Anoxia / metabolism,  physiopathology*
Bronchoconstriction / drug effects,  physiology
Chronic Disease
Cyclic AMP / blood
Histamine / pharmacology
Lung / metabolism
Male
Myocardium / metabolism
Potassium / blood
Rabbits
Tissue Distribution
Chemical
Reg. No./Substance:
18559-94-9/Albuterol; 51-45-6/Histamine; 60-92-4/Cyclic AMP; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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