Document Detail

Influence of chronic hypoxemia on peripheral muscle function and oxidative stress in humans.
MedLine Citation:
PMID:  15056179     Owner:  NLM     Status:  MEDLINE    
Transient re-oxygenation of humans suffering from chronic obstructive pulmonary disease (COPD) allows the assessment of the consequences of chronic hypoxemia on peripheral muscle and metabolism apart from the effects of de-conditioning. The subjects performed maximal voluntary contractions (MVC) of flexor digitorum and vastus lateralis muscles and sustained infra-maximal contractions. COPD patients repeated the whole challenge during a 50-min oxygen breathing period and after recovery to baseline hypoxemia. We measured the compound evoked muscle mass action potential (M-wave) and the medium frequency (MF) of surface electromyography (EMG) power spectrum. Blood lactate (LA) and potassium (K+), erythrocyte-reduced glutathione (GSH), and plasma thiobarbituric acid reactive substances (TBARS) were also measured. Compared with a control group, COPD patients had lower MVCs, an attenuated decrease in MF during exercise, lower resting level of GSH, no posthandgrip TBARS increase and no GSH consumption. Reoxygenation (1) increased MVCs, (2) accentuated the MF decline and (3) elicited a posthandgrip TBARS increase and GSH consumption. Thus, we conclude that chronic hypoxemia exerts specific muscular effects: a reduced force production, an attenuated 'muscle wisdom', and the suppression of the exercise oxidative stress.
Marion Faucher; Jean Guillaume Steinberg; Dominique Barbier; François Hug; Yves Jammes
Related Documents :
11510809 - Dose-response effect of oxygen on hyperinflation and exercise endurance in nonhypoxaemi...
23548859 - Impaired brachial artery flow-mediated vasodilation in response to handgrip exercise-in...
12454299 - Randomised controlled trial of transcutaneous electrical muscle stimulation of the lowe...
18270219 - Exercise capacity after lobectomy in patients with chronic obstructive pulmonary disease.
2711379 - Change in p wave height during progressive exercise in patients with chronic obstructiv...
17475459 - Effect of tiotropium bromide on the cardiovascular response to exercise in copd.
16370659 - Comparison of three psychological defense mechanism questionnaires.
8975029 - Wandering behaviors in institutionalized persons with dementia.
12877289 - Quantification and aging of the post-blast residue of tnt landmines.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical physiology and functional imaging     Volume:  24     ISSN:  1475-0961     ISO Abbreviation:  Clin Physiol Funct Imaging     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-04-01     Completed Date:  2004-06-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101137604     Medline TA:  Clin Physiol Funct Imaging     Country:  England    
Other Details:
Languages:  eng     Pagination:  75-84     Citation Subset:  IM    
Laboratoire de Physiopathologie Respiratoire (EA 2201), Faculté de Mèdecine, Institut Jean Roche, Université de la Méditerranée, Marseille, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anoxia / blood,  physiopathology*
Chronic Disease
Evoked Potentials
Glutathione / blood
Lactic Acid / blood
Muscle Contraction
Muscle, Skeletal / physiopathology*
Osmolar Concentration
Oxidative Stress*
Physical Endurance
Potassium / blood
Pulmonary Disease, Chronic Obstructive / blood,  physiopathology*
Respiratory Function Tests
Thiobarbituric Acid Reactive Substances / analysis
Work of Breathing
Reg. No./Substance:
0/Thiobarbituric Acid Reactive Substances; 50-21-5/Lactic Acid; 70-18-8/Glutathione; 7440-09-7/Potassium; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Lung fractional moving blood volume in normally grown and growth restricted foetuses.
Next Document:  Comparison of hand-to-hand bioimpedance and anthropometry equations versus dual-energy X-ray absorpt...