Document Detail

Influence of chronic hypoxemia on peripheral muscle function and oxidative stress in humans.
MedLine Citation:
PMID:  15056179     Owner:  NLM     Status:  MEDLINE    
Transient re-oxygenation of humans suffering from chronic obstructive pulmonary disease (COPD) allows the assessment of the consequences of chronic hypoxemia on peripheral muscle and metabolism apart from the effects of de-conditioning. The subjects performed maximal voluntary contractions (MVC) of flexor digitorum and vastus lateralis muscles and sustained infra-maximal contractions. COPD patients repeated the whole challenge during a 50-min oxygen breathing period and after recovery to baseline hypoxemia. We measured the compound evoked muscle mass action potential (M-wave) and the medium frequency (MF) of surface electromyography (EMG) power spectrum. Blood lactate (LA) and potassium (K+), erythrocyte-reduced glutathione (GSH), and plasma thiobarbituric acid reactive substances (TBARS) were also measured. Compared with a control group, COPD patients had lower MVCs, an attenuated decrease in MF during exercise, lower resting level of GSH, no posthandgrip TBARS increase and no GSH consumption. Reoxygenation (1) increased MVCs, (2) accentuated the MF decline and (3) elicited a posthandgrip TBARS increase and GSH consumption. Thus, we conclude that chronic hypoxemia exerts specific muscular effects: a reduced force production, an attenuated 'muscle wisdom', and the suppression of the exercise oxidative stress.
Marion Faucher; Jean Guillaume Steinberg; Dominique Barbier; François Hug; Yves Jammes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical physiology and functional imaging     Volume:  24     ISSN:  1475-0961     ISO Abbreviation:  Clin Physiol Funct Imaging     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-04-01     Completed Date:  2004-06-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101137604     Medline TA:  Clin Physiol Funct Imaging     Country:  England    
Other Details:
Languages:  eng     Pagination:  75-84     Citation Subset:  IM    
Laboratoire de Physiopathologie Respiratoire (EA 2201), Faculté de Mèdecine, Institut Jean Roche, Université de la Méditerranée, Marseille, France.
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MeSH Terms
Anoxia / blood,  physiopathology*
Chronic Disease
Evoked Potentials
Glutathione / blood
Lactic Acid / blood
Muscle Contraction
Muscle, Skeletal / physiopathology*
Osmolar Concentration
Oxidative Stress*
Physical Endurance
Potassium / blood
Pulmonary Disease, Chronic Obstructive / blood,  physiopathology*
Respiratory Function Tests
Thiobarbituric Acid Reactive Substances / analysis
Work of Breathing
Reg. No./Substance:
0/Thiobarbituric Acid Reactive Substances; 50-21-5/Lactic Acid; 70-18-8/Glutathione; 7440-09-7/Potassium; 7782-44-7/Oxygen

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