| Influence of chronic hypoxemia on peripheral muscle function and oxidative stress in humans. | |
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MedLine Citation:
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PMID: 15056179 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Transient re-oxygenation of humans suffering from chronic obstructive pulmonary disease (COPD) allows the assessment of the consequences of chronic hypoxemia on peripheral muscle and metabolism apart from the effects of de-conditioning. The subjects performed maximal voluntary contractions (MVC) of flexor digitorum and vastus lateralis muscles and sustained infra-maximal contractions. COPD patients repeated the whole challenge during a 50-min oxygen breathing period and after recovery to baseline hypoxemia. We measured the compound evoked muscle mass action potential (M-wave) and the medium frequency (MF) of surface electromyography (EMG) power spectrum. Blood lactate (LA) and potassium (K+), erythrocyte-reduced glutathione (GSH), and plasma thiobarbituric acid reactive substances (TBARS) were also measured. Compared with a control group, COPD patients had lower MVCs, an attenuated decrease in MF during exercise, lower resting level of GSH, no posthandgrip TBARS increase and no GSH consumption. Reoxygenation (1) increased MVCs, (2) accentuated the MF decline and (3) elicited a posthandgrip TBARS increase and GSH consumption. Thus, we conclude that chronic hypoxemia exerts specific muscular effects: a reduced force production, an attenuated 'muscle wisdom', and the suppression of the exercise oxidative stress. |
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Authors:
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Marion Faucher; Jean Guillaume Steinberg; Dominique Barbier; François Hug; Yves Jammes |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical physiology and functional imaging Volume: 24 ISSN: 1475-0961 ISO Abbreviation: Clin Physiol Funct Imaging Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-04-01 Completed Date: 2004-06-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101137604 Medline TA: Clin Physiol Funct Imaging Country: England |
Other Details:
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Languages: eng Pagination: 75-84 Citation Subset: IM |
Affiliation:
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Laboratoire de Physiopathologie Respiratoire (EA 2201), Faculté de Mèdecine, Institut Jean Roche, Université de la Méditerranée, Marseille, France. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anoxia / blood, physiopathology* Chronic Disease Electromyography Evoked Potentials Female Glutathione / blood Humans Lactic Acid / blood Male Muscle Contraction Muscle, Skeletal / physiopathology* Osmolar Concentration Oxidative Stress* Oxygen Physical Endurance Potassium / blood Pulmonary Disease, Chronic Obstructive / blood, physiopathology* Respiration Respiratory Function Tests Thiobarbituric Acid Reactive Substances / analysis Work of Breathing |
| Chemical | |
Reg. No./Substance:
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0/Thiobarbituric Acid Reactive Substances; 50-21-5/Lactic Acid; 70-18-8/Glutathione; 7440-09-7/Potassium; 7782-44-7/Oxygen |
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