Document Detail

Influence of chorioamnionitis on survival and morbidity in singletons live-born at < 32 weeks of gestation.
MedLine Citation:
PMID:  11304970     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Chorioamnionitis (CAM) may accelerate lung maturation in fetuses. It is possible that CAM prevents infant death after live birth. METHODS: A retrospective study of live-born singletons at < 32 weeks of gestation between 1993 and 1997. Perinatal risk factors for adverse outcomes were analyzed using a logistic regression model, with special reference to the presence of histologically confirmed CAM. Adverse outcomes included infant death before 1 year of age, and survival with cerebral palsy and/or mental retardation. RESULTS: A total of 81 infants, weighing 1181 +/- 426 g, were born at 28.1 +/- 2.3 weeks of gestation. Of those, 15 (19%) died before 1 year of age, while 16 (20%) infants developed major handicaps by 1.5 years of age (six with cerebral palsy, eight with mental retardation, and two with both cerebral palsy and mental retardation). CAM, present in 44 women, was significantly associated with a reduced risk of death after live birth, with an odds ratio of 0.11 (p = 0.01). Only the presence of such intracranial lesions as periventricular leukomalacia and intraventricular hemorrhage were significantly associated with an increased risk of major handicaps (odds ratio of 11.0, p = 0.04). Adverse outcomes occurred in a similar proportion of infants in groups without CAM (14/37) and with CAM (17/44). However, among infants with adverse outcomes, the number of deaths was significantly higher in the group without CAM (10/14) vs. with CAM (5/12) (p < 0.05). CONCLUSIONS: The presence of CAM may somehow prevent infant death after live birth. Larger studies are required to confirm this phenomenon.
S Kosuge; A Ohkuchi; H Minakami; S Matsubara; A Uchida; Y Eguchi; Y Honma; I Sato
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  79     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2001-04-17     Completed Date:  2001-05-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  861-5     Citation Subset:  IM    
Center for Perinatal Medicine, Jichi Medical School Hospital, Minamikawachi-machi, Tochigi, Japan.
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MeSH Terms
Cerebral Palsy / etiology
Chorioamnionitis / physiopathology*
Gestational Age
Infant Mortality*
Infant, Newborn
Infant, Premature*
Infant, Premature, Diseases / drug therapy,  etiology
Infant, Very Low Birth Weight / growth & development
Logistic Models
Mental Retardation / etiology
Multivariate Analysis
Retrospective Studies
Risk Factors

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