| Influence of chlorpromazine on lysosomal alterations during myocardial ischaemia. | |
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MedLine Citation:
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PMID: 6883416 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ligation of the circumflex artery of anaesthetised, open-chest rabbits caused a progressive increase in nonsedimentable cathepsin D activity in severely ischaemic myocardium and an anatomical redistribution of the enzyme from lysosomes into the cytosol, along with progressive ultrastructural signs of cellular damage and necrosis. Chlorpromazine pretreatment (15 mg X kg-1 intravenously) reduced the increase in nonsedimentable cathepsin D activity slightly, but no appreciable protective effect on the anatomical redistribution of the enzyme or the development of ultrastructural signs of necrosis could be detected. It is concluded that in this experimental model of myocardial infarction, high concentrations of chlorpromazine have a mild stabilising action on lysosomes, but the drug has minimal if any effect in protecting the heart from ischaemic damage. |
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Authors:
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K R Chien; J S Crie; R S Decker; K Wildenthal |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cardiovascular research Volume: 17 ISSN: 0008-6363 ISO Abbreviation: Cardiovasc. Res. Publication Date: 1983 Jul |
Date Detail:
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Created Date: 1983-10-28 Completed Date: 1983-10-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 407-14 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cathepsin D Cathepsins / metabolism Chlorpromazine / therapeutic use* Coronary Disease / drug therapy*, enzymology Disease Models, Animal Lysosomes / drug effects*, enzymology Male Microscopy, Electron Myocardium / enzymology, ultrastructure Rabbits |
| Grant Support | |
ID/Acronym/Agency:
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HL-07360/HL/NHLBI NIH HHS; HL-17669/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-53-3/Chlorpromazine; EC 3.4.-/Cathepsins; EC 3.4.23.5/Cathepsin D |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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