Document Detail


Influence of chlorpromazine on lysosomal alterations during myocardial ischaemia.
MedLine Citation:
PMID:  6883416     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ligation of the circumflex artery of anaesthetised, open-chest rabbits caused a progressive increase in nonsedimentable cathepsin D activity in severely ischaemic myocardium and an anatomical redistribution of the enzyme from lysosomes into the cytosol, along with progressive ultrastructural signs of cellular damage and necrosis. Chlorpromazine pretreatment (15 mg X kg-1 intravenously) reduced the increase in nonsedimentable cathepsin D activity slightly, but no appreciable protective effect on the anatomical redistribution of the enzyme or the development of ultrastructural signs of necrosis could be detected. It is concluded that in this experimental model of myocardial infarction, high concentrations of chlorpromazine have a mild stabilising action on lysosomes, but the drug has minimal if any effect in protecting the heart from ischaemic damage.
Authors:
K R Chien; J S Crie; R S Decker; K Wildenthal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cardiovascular research     Volume:  17     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-10-28     Completed Date:  1983-10-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  407-14     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cathepsin D
Cathepsins / metabolism
Chlorpromazine / therapeutic use*
Coronary Disease / drug therapy*,  enzymology
Disease Models, Animal
Lysosomes / drug effects*,  enzymology
Male
Microscopy, Electron
Myocardium / enzymology,  ultrastructure
Rabbits
Grant Support
ID/Acronym/Agency:
HL-07360/HL/NHLBI NIH HHS; HL-17669/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
50-53-3/Chlorpromazine; EC 3.4.-/Cathepsins; EC 3.4.23.5/Cathepsin D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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