Document Detail

Influence of change in lateral decubitus on pulmonary aerosol deposition.
MedLine Citation:
PMID:  21971723     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The lateral decubitus position leads to the greatest changes in regional pulmonary ventilation and is used in respiratory physical therapy routines.
OBJECTIVES: To evaluate the influence of the lateral decubitus position on the pulmonary deposition of inhaled radioaerosol particles in young people and report the effects of the decubitus position on routine therapy.
METHODS: Eight healthy male volunteers, mean age 23.6±2.5 years, were included in a randomized study in two phases. In the first phase, aerosol was inhaled for nine minutes in a randomly-selected lateral decubitus position and after an interval of 5 to 7 days, the second phase was conducted. Pulmonary scintigraphy was carried out by inhalation of 25 mCi of 99mTc-DTPA. Following inhalation, images were acquired with scintillation cameras and regions of interest (ROI) were investigated in the longitudinal and cross-sectional divisions of the lungs. Statistical analysis included a paired Student's t-test with a significance level of p≤0.05.
RESULTS: Inhalation in the right lateral decubitus position presented higher counts (p≤0.04) in posterior ROI of the right lung than in the posterior ROI of the left lung. In the left lateral decubitus position, the count was higher in the left lung (p≤0.02) than in the posterior ROI of the right lung.
CONCLUSIONS: The deposition of aerosol particles during inhalation was position-dependent in the two phases of the study, which confirms the validity of technical and therapeutic resources based on the physiology of position-dependent ventilation and suggests that body positioning can be used to advantage in routine therapy.
Luciana Alcoforado; Luiz C Pessôa Filho; Daniella C Brandão; André M Galvão; Cyda M A Reinaux; Armèle Dornelas de Andrade
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Revista brasileira de fisioterapia (São Carlos (São Paulo, Brazil))     Volume:  15     ISSN:  -     ISO Abbreviation:  Rev Bras Fisioter     Publication Date:    2011 Aug-Sep
Date Detail:
Created Date:  2011-10-05     Completed Date:  2012-02-13     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  101186153     Medline TA:  Rev Bras Fisioter     Country:  Brazil    
Other Details:
Languages:  eng; por     Pagination:  278-83     Citation Subset:  IM    
Laboratory of Cardiorespiratory Physical Therapy, Physical Therapy Department, Universidade Federal de Pernambuco, Recife, PE, Brasil.
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MeSH Terms
Aerosols / metabolism*
Lung / metabolism*
Patient Positioning* / methods
Young Adult
Reg. No./Substance:

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