Document Detail


Influence of cerebrovascular arteriosclerosis on cerebral oxygenation during exercise.
MedLine Citation:
PMID:  17457009     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Although it is assumed that cerebral oxygenation during exercise is influenced by both cardiopulmonary function and cerebrovascular arteriosclerosis, the latter factor has not been fully clarified. In the present study the relationship between the degree of cerebrovascular arteriosclerosis and cerebral oxygenation during exercise was investigated. METHODS AND RESULTS: A total of 109 patients (69 patients with coronary artery disease, 40 patients with hypertensive heart disease) (61.7+/-9.7 years) performed a symptom-limited exercise test with respiratory gas measurements (CPX). From the respiratory gas analysis, peak O(2) uptake (VO(2)), the slope of the increase in VO(2) to the increase in work rate (DeltaVO (2)/DeltaWR), and the slope of the increase in ventilation to the increase in CO(2) output (VE/VCO(2) slope) were calculated. Oxyhemoglobin (O(2)Hb) at the forehead was monitored using near-infrared spectroscopy. The brain ischemic score was counted based upon fluid-attenuated inversion recovery images of magnetic resonance imaging and expressed from 0 to 4. When compared with patients with a lower ischemic score (<2, n=67), those with a higher ischemic score (> or =2, n=42) had a lower increase in brain O(2)Hb during exercise (-1.08 +/-2.7 vs 0.77+/-4.1 micromol/L, p=0.011). Of brain ischemic score, left ventricular ejection fraction, peak VO(2), DeltaVO(2)/DeltaWR, and the VE/VCO(2) slope, DeltaVO(2)/ DeltaWR was found to be the sole independent index determining cerebral O(2)Hb during exercise. The CPX parameters were also significantly related to the degree of cerebrovascular arteriosclerosis. CONCLUSIONS: Although cerebral oxygenation during exercise is mainly related to cardiopulmonary function, the degree of cerebrovascular arteriosclerosis partly influences cerebral oxygenation in patients with risk factors for atherosclerosis.
Authors:
Osamu Nagayama; Akira Koike; Masayo Hoshimoto; Kaori Yamaguchi; Akihiko Tajima; Ayumi Goda; Tokuhisa Uejima; Haruki Itoh; Tadanori Aizawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  71     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-25     Completed Date:  2007-05-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  782-7     Citation Subset:  IM    
Affiliation:
The Cardiovascular Institute, Minato-ku, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Brain / metabolism*
Brain Ischemia / metabolism,  physiopathology
Carbon Dioxide
Exercise*
Exhalation
Female
Heart / physiopathology
Humans
Intracranial Arteriosclerosis / metabolism,  physiopathology*
Lung / physiopathology
Magnetic Resonance Angiography
Magnetic Resonance Imaging
Male
Middle Aged
Oxygen Consumption*
Oxyhemoglobins / metabolism
Spectroscopy, Near-Infrared
Stroke Volume
Chemical
Reg. No./Substance:
0/Oxyhemoglobins; 124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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