| Influence of castration-induced testosterone and estradiol deficiency on obesity and glucose metabolism in male Göttingen minipigs. | |
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MedLine Citation:
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PMID: 20420845 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Low testosterone and estradiol concentrations are predictive for the development of the metabolic syndrome in men and women, respectively. The aim of this study was to investigate the influence of sex hormone deficiency on food intake, body weight, body composition and glucose metabolism in male Göttingen minipigs. Five adult male Göttingen minipigs were studied before castration (pre-cast), 10-18 days (post-cast 1) and 10-11 weeks (post-cast 2) after castration. Parameters of interest were food intake, body weight, body fat percentage and sex hormone concentrations. Furthermore glucose tolerance, glucagon suppression, insulin resistance, beta cell function and disposition index were evaluated by oral and intravenous glucose tolerance tests. Castration led to almost complete disappearance of circulating testosterone and estradiol and secondarily to increased food intake, body weight and body fat percentage. Ten-eighteen days sex hormone deficiency (post-cast 1) did not significantly change any of the investigated metabolic parameters compared to pre-cast levels. Ten weeks after castration (post-cast 2) significant insulin resistance, glucose intolerance and hyperglucagonemia was found, and the beta cell function and the disposition index both were decreased. In conclusion, castration-induced sex hormone deficiency in male Göttingen minipigs results in hyperphagia, obesity and disturbed glucose metabolism, which are some of the features typical for the human metabolic syndrome. |
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Authors:
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Berit Oestergaard Christoffersen; Laust Peter Gade; Valeria Golozoubova; Ove Svendsen; Kirsten Raun |
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Publication Detail:
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Type: Journal Article Date: 2010-04-24 |
Journal Detail:
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Title: Steroids Volume: 75 ISSN: 1878-5867 ISO Abbreviation: Steroids Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-10-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404536 Medline TA: Steroids Country: United States |
Other Details:
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Languages: eng Pagination: 676-84 Citation Subset: IM |
Affiliation:
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Veterinary Pathobiology, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark. BQC@novonordisk.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Composition / physiology Body Weight / physiology Castration* Eating / physiology Estradiol / deficiency, metabolism* Glucose Intolerance / blood, physiopathology Glucose Tolerance Test Insulin Resistance / physiology Male Obesity / blood, metabolism Swine Swine, Miniature Testosterone / deficiency, metabolism* |
| Chemical | |
Reg. No./Substance:
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50-28-2/Estradiol; 58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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