Document Detail

Influence of carvedilol on the benefits of physical training in patients with moderate chronic heart failure.
MedLine Citation:
PMID:  11378005     Owner:  NLM     Status:  MEDLINE    
AIMS: To evaluate prospectively the impact of carvedilol on a short-term physical training program in stable patients with moderate chronic heart failure (CHF), and to analyze parameters predictive of improvement after training.
METHODS AND RESULTS: Thirty-eight patients with CHF were referred for cardiac rehabilitation. Etiology was ischemic in 26 patients, dilated in 12 patients and left ventricular ejection fraction was <35%. Patients were classified into three groups: group 1 (n=14)=ACE inhibitors, diuretics and digitalis; group 2 (n=11)=idem group 1+cardioselective beta-blocker; group 3 (n=13)=idem group 1+carvedilol. Exercise tests with VO2 measurement were performed before and after a 4-week exercise training program. Patients with carvedilol experienced a 16.6% increase in peak VO2 which was similar to the 13.9% increase in the group with cardioselective beta-blocker and to the 18.5% in the group without beta-blocker. Moreover non-ischemic etiology of CHF was the only parameter predictive of improvement after training (P=0.02).
CONCLUSION: Addition of carvedilol did not alter benefits of a short-term physical training program in patients with moderate CHF. No baseline characteristic except for etiology of CHF was predictive of a response to training.
J F Forissier; P Vernochet; P Bertrand; B Charbonnier; C Monpère
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of heart failure     Volume:  3     ISSN:  1388-9842     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-05-29     Completed Date:  2001-08-30     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  335-42     Citation Subset:  IM    
Centre de réadaptation cardiovasculaire Bois-Gibert, 37510, Ballan-Miré, France.
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MeSH Terms
Acebutolol / therapeutic use
Adrenergic beta-Antagonists / therapeutic use*
Angiotensin-Converting Enzyme Inhibitors / therapeutic use
Carbazoles / therapeutic use*
Chronic Disease
Exercise Test / methods
Heart Failure / drug therapy*,  etiology,  rehabilitation*
Heart Rate / drug effects,  physiology
Middle Aged
Multivariate Analysis
Oxygen Consumption / drug effects,  physiology
Physical Therapy Modalities
Predictive Value of Tests
Propanolamines / therapeutic use*
Prospective Studies
Stroke Volume / drug effects,  physiology
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Carbazoles; 0/Propanolamines; 0K47UL67F2/carvedilol; 37517-30-9/Acebutolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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