| Influence of carvedilol on the benefits of physical training in patients with moderate chronic heart failure. | |
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MedLine Citation:
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PMID: 11378005 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To evaluate prospectively the impact of carvedilol on a short-term physical training program in stable patients with moderate chronic heart failure (CHF), and to analyze parameters predictive of improvement after training. METHODS AND RESULTS: Thirty-eight patients with CHF were referred for cardiac rehabilitation. Etiology was ischemic in 26 patients, dilated in 12 patients and left ventricular ejection fraction was <35%. Patients were classified into three groups: group 1 (n=14)=ACE inhibitors, diuretics and digitalis; group 2 (n=11)=idem group 1+cardioselective beta-blocker; group 3 (n=13)=idem group 1+carvedilol. Exercise tests with VO2 measurement were performed before and after a 4-week exercise training program. Patients with carvedilol experienced a 16.6% increase in peak VO2 which was similar to the 13.9% increase in the group with cardioselective beta-blocker and to the 18.5% in the group without beta-blocker. Moreover non-ischemic etiology of CHF was the only parameter predictive of improvement after training (P=0.02). CONCLUSION: Addition of carvedilol did not alter benefits of a short-term physical training program in patients with moderate CHF. No baseline characteristic except for etiology of CHF was predictive of a response to training. |
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Authors:
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J F Forissier; P Vernochet; P Bertrand; B Charbonnier; C Monpère |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: European journal of heart failure Volume: 3 ISSN: 1388-9842 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-05-29 Completed Date: 2001-08-30 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 335-42 Citation Subset: IM |
Affiliation:
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Centre de réadaptation cardiovasculaire Bois-Gibert, 37510, Ballan-Miré, France. bgibert@club-internet.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acebutolol
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therapeutic use Adrenergic beta-Antagonists / therapeutic use* Adult Aged Angiotensin-Converting Enzyme Inhibitors / therapeutic use Carbazoles / therapeutic use* Chronic Disease Exercise Test / methods Female Heart Failure / drug therapy*, etiology, rehabilitation* Heart Rate / drug effects, physiology Humans Male Middle Aged Multivariate Analysis Oxygen Consumption / drug effects, physiology Physical Therapy Modalities Predictive Value of Tests Propanolamines / therapeutic use* Prospective Studies Stroke Volume / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Carbazoles; 0/Propanolamines; 37517-30-9/Acebutolol; 72956-09-3/carvedilol |
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