Document Detail


Influence of carrageenan on the rheology and skin permeation of microemulsion formulations.
MedLine Citation:
PMID:  14980774     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three different microemulsions (A-C) and one semisolid preparation D were investigated in terms of viscoelastic properties and skin permeation of the model compound sodium fluorescein. The influence of the polysaccharide carrageenan on these parameters was investigated. Carrageenan is frequently used as food additive and has very interesting properties like good adhesiveness on skin which can be a benefit for topical application. The viscoelastic properties of the preparations (A-D) and of mixtures with carrageenan (A'-D') were characterized by oscillatory measurements. It was possible to adjust the rheologic properties of the formulations and to increase the sodium fluorescein permeation through porcine skin by mixing them with carrageenan gels. Therefore, the presented formulations as well as mixtures with carrageenan might be promising alternative drug carrier systems for topical pharmaceutical as well as cosmetics.
Authors:
Claudia Valenta; Katharina Schultz
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Journal of controlled release : official journal of the Controlled Release Society     Volume:  95     ISSN:  0168-3659     ISO Abbreviation:  J Control Release     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-02-24     Completed Date:  2004-10-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8607908     Medline TA:  J Control Release     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  257-65     Citation Subset:  IM    
Affiliation:
Institute of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria. Claudia.Valenta@univie.ac.at
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MeSH Terms
Descriptor/Qualifier:
Animals
Carrageenan / pharmacology*
Cations / chemistry
Chemistry, Pharmaceutical
Diffusion
Drug Incompatibility
Elasticity
Emulsions*
Ethanol / chemistry
Excipients*
Fluorescein
Freeze Drying
Rheology
Skin Absorption / drug effects*
Swine
Viscosity
Chemical
Reg. No./Substance:
0/Cations; 0/Emulsions; 0/Excipients; 2321-07-5/Fluorescein; 64-17-5/Ethanol; 9000-07-1/Carrageenan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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