| Influence of cardiac rehabilitation on natriuretic peptides. | |
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MedLine Citation:
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PMID: 22032060 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: Cardiac rehabilitation programmes result in reduced morbidity and mortality and improvement of functional class. Behaviour of natriuretic peptides coupled to these programmes is not well established. Our study's objective is to evaluate the behaviour of natriuretic peptides in a sample of patients undergoing a cardiac rehabilitation programme. METHODS AND RESULTS: Moderate to high-risk patients undergoing a cardiac rehabilitation programme were included. Demographic and clinical characteristics were recorded. We performed four N-terminal pro-brain natriuretic peptide (NT-proBNP) plasma determinations: on the first and last programme day, before and after training. To evaluate functional capacity, a stress test before and after the exercise programme was performed. Eighty-three patients were included. Exercise produces increased levels of NT-proBNP, although in the last exercise session the increase was lower (35.91 vs. 31.49 ng/ml (P = 0.71)). Patients with left ventricular dysfunction present higher NT-proBNP levels. After the rehabilitation programme we observed a significant improvement of functional capacity by 1.5 METS on average (P = 0.001), but not in the subgroup with lower NT-proBNP levels. CONCLUSIONS: Basal levels of peptides did not change significantly after the programme but rose with the workout, especially in patients with left ventricular dysfunction. Patients with higher baseline levels obtained greater functional recovery. We conclude that NT-proBNP measurement may be useful in selecting patients to perform a cardiac rehabilitation programme. |
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Authors:
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Angel Montiel-Trujillo; Guillermo Isasti-Aizpurua; Fernando Carrasco-Chinchilla; Manuel F Jiménez-Navarro; Adela Gómez-González; José C Bravo Navas; Cristina Jimeno; Eduardo De Teresa-Galván |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta cardiologica Volume: 66 ISSN: 0001-5385 ISO Abbreviation: Acta Cardiol Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370570 Medline TA: Acta Cardiol Country: Belgium |
Other Details:
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Languages: eng Pagination: 641-3 Citation Subset: IM |
Affiliation:
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Cardiology Department, Hospital Clinico Universitario Virgen de la Victoria, Malaga, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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