Document Detail


Influence of a carcinogenic agent, 7.12 dimethylbenz (alpha) anthracene (DMBA), on production of interferon alpha/beta in murine and human cells.
MedLine Citation:
PMID:  3014815     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Interferon production in mouse and human cells induced by paramyxovirus was inhibited by pretreatment of cells with 7.12 dimethylbenz (alpha) anthracene. The inhibition was moderate but reproducible. It was most pronounced in mouse fibroblast cells, somewhat less in the mouse L-929 cell line and in human embryo fibroblast cells. Addition of the microsomal activator systems was necessary in the human system. A possible employment of this phenomenon in testing carcinogenic potential is discussed.
Authors:
M Degré; M Holberg-Petersen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta pathologica, microbiologica, et immunologica Scandinavica. Section B, Microbiology     Volume:  94     ISSN:  0108-0180     ISO Abbreviation:  Acta Pathol Microbiol Immunol Scand B     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-08-01     Completed Date:  1986-08-01     Revised Date:  2009-06-04    
Medline Journal Info:
Nlm Unique ID:  8206623     Medline TA:  Acta Pathol Microbiol Immunol Scand B     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  51-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
9,10-Dimethyl-1,2-benzanthracene / pharmacology*
Animals
Cell Line
Fibroblasts / metabolism
Humans
Interferon Type I / biosynthesis*
Mice
Newcastle disease virus
Parainfluenza Virus 1, Human
Chemical
Reg. No./Substance:
0/Interferon Type I; 57-97-6/9,10-Dimethyl-1,2-benzanthracene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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