Document Detail


Influence of captopril, propranolol, and verapamil on arterial pulse wave velocity and other cardiovascular parameters in healthy volunteers.
MedLine Citation:
PMID:  9760009     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The effects of antihypertensive agents on cardiovascular parameters, especially on arterial pulse wave velocity, remain largely unknown in normotensive subjects. Therefore, the present investigation was designed to evaluate acute effects of ACE inhibitor captopril,beta-adrenoceptor blocker propranolol and calcium entry blocker verapamil on cardiovascular and ventilatory function in healthy volunteers. MATERIAL: The influence of single doses of captopril (25 mg), propranolol (40 mg), and verapamil (80 mg) on cardiovascular function and exercise capacity were compared in healthy volunteers in a randomized, double-blind, placebo-controlled fashion. METHODS: Cardiac output and beat-by-beat blood pressure were estimated non-invasively before and after the drug administrations by whole-body impedance cardiography and Finapres finger blood pressure monitoring, respectively. Arterial pulse wave velocity was obtained from the time delay between flow pulses measured from the root of the aorta and the popliteal artery, and systemic vascular resistance was calculated from cardiac output and mean arterial pressure. In addition, a progressive maximal exercise test was performed after the treatments. RESULTS: Propranolol reduced heart rate, cardiac output and arterial pulse wave velocity, and increased systemic vascular resistance clearly more effectively than placebo. In addition, captopril effectively decreased arterial resistance and pulse wave velocity. However, the influence of verapamil on cardiovascular parameters did not significantly differ from those observed in placebo-treated subjects. Exercise peak heart rate, peak blood pressure, and minute ventilation were reduced in subjects treated with propranolol, but not in those treated with captopril and verapamil, when compared to placebo. CONCLUSIONS: Acute administration of captopril and propranolol but not verapamil clearly modulated cardiovascular parameters in rest, suggesting differential effects of these compounds on cardiovascular function in healthy volunteers. These drugs seem to have disparate effects on arterial pulse wave propagation as an indicator of arterial compliance after short-term administration in healthy subjects. Captopril and verapamil had no effect on cardiovascular and ventilatory function during maximal exercise, while propranolol markedly altered also these variables in the present study.
Authors:
M Kähönen; R Ylitalo; T Kööbi; V Turjanmaa; P Ylitalo
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of clinical pharmacology and therapeutics     Volume:  36     ISSN:  0946-1965     ISO Abbreviation:  Int J Clin Pharmacol Ther     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-12-11     Completed Date:  1998-12-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9423309     Medline TA:  Int J Clin Pharmacol Ther     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  483-9     Citation Subset:  IM    
Affiliation:
Department of Pharmacological Sciences, University of Tampere, Finland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antihypertensive Agents / pharmacology*
Arteries / drug effects*
Blood Pressure / drug effects
Captopril / pharmacology*
Cardiac Output / drug effects
Double-Blind Method
Female
Heart Rate / drug effects
Hemodynamics / drug effects*
Humans
Male
Propranolol / pharmacology*
Pulsatile Flow / drug effects*
Pulse*
Respiratory Mechanics / drug effects
Verapamil / pharmacology*
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 52-53-9/Verapamil; 525-66-6/Propranolol; 62571-86-2/Captopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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