Document Detail


Influence of canrenoate-K and cardiac glycosides on their tissue distribution and elimination.
MedLine Citation:
PMID:  578485     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The combination of cardiac glycosides and canrenoate-potassium (CR-K) produces synergistic effects on hemodynamics. On the other hand, CR-K antagonizes digitalis-induced cardiac arrhythmias. Therefore, it was the purpose of this study to determine interactions between these substances, particularly of their myocardial uptake. The additional administration of CR-K leads to significantly higher concentrations of digoxin and ouabain in heart, liver, adrenal gland and spleen. Contrary to this, additional digoxin reduces the concentration of CR-K in the tissue. Particularly obvious is the reduced concentration in the kidney, adrenal gland, pancreas, brain and spleen. The renal excretion of digoxin and ouabain is reduced by the additional administration of CR-K, while digoxin accelerates the CR-K excretion within the first 60 min after application. Metabolic interference was not detected in the combination of cardiac glycosides and CR-K. The mechanisms for the interactions between cardiac glycosides and CR-K during the distribution phase are discussed. The inhomogenous interference of their myocardial uptake makes a common cardiac receptor for the synergistic effect of cardiac glycosides and CR-K rather unlikely. CR-K does not have a suppressant effect on digitalis-induced arrhythmias due to any diminution of the glycoside uptake by myocardial tissue.
Authors:
J Kuhlmann; V Kötter; H F Vöhringer; N Rietbrock; R Schröder
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  27     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1977 Jul 
Date Detail:
Created Date:  1977-10-31     Completed Date:  1977-10-31     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  1505-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Canrenoate Potassium / metabolism,  pharmacology*
Chromatography, Thin Layer
Digoxin / metabolism,  pharmacology*
Dogs
Drug Interactions
Myocardium / metabolism
Ouabain / metabolism,  pharmacology*
Pregnadienes / pharmacology*
Time Factors
Chemical
Reg. No./Substance:
0/Pregnadienes; 20830-75-5/Digoxin; 2181-04-6/Canrenoate Potassium; 630-60-4/Ouabain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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