Document Detail


Influence of bulk and tapped density on the determination of the thermal conductivity of powders and blends.
MedLine Citation:
PMID:  17915828     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to evaluate a non-steady-state needle sensor to determine the thermal conductivity (lambda) of powders and their blends. It was investigated how lambda of different powders was influenced by (1) bulk vs tapped density, (2) moisture content of the powders, and (3) blending time of the powders. Different powders were evaluated: 2 lactose powders with different properties, a microcrystalline cellulose powder, a cornstarch powder, and 3 herbal extracts. The results show that the values of lambda are highly dependent on the bulk and tapped density of the powders. Bulk density measurements were generally not sensitive enough to detect the moisture content within a powder. The tapped density measurements were reliable and highly reproducible and could differentiate between the nature of a powder and the powder moisture content. Measurements of lambda were able to be used to monitor the powder blending process. To be able to use thermal conductivity measurements to characterize powder properties in quality control, the powder density must be defined because changes in density affect lambda. Using thermal conductivity as a measure for process analytical technology seems to be feasible and can add valuable information to the process under investigation.
Authors:
Kendra Schröder; Katja Schmid; Raimar Löbenberg
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Publication Detail:
Type:  Journal Article     Date:  2007-09-28
Journal Detail:
Title:  AAPS PharmSciTech     Volume:  8     ISSN:  1530-9932     ISO Abbreviation:  AAPS PharmSciTech     Publication Date:  2007  
Date Detail:
Created Date:  2007-10-05     Completed Date:  2007-10-17     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  100960111     Medline TA:  AAPS PharmSciTech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E78     Citation Subset:  IM    
Affiliation:
Institut für Pharmazie, University of Hamburg, 20146 Hamburg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Powders / chemistry*
Technology, Pharmaceutical*
Thermal Conductivity
Chemical
Reg. No./Substance:
0/Powders
Comments/Corrections

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