| Influence of bronchial blood flow and conductance on pulmonary function in stable systolic heart failure. | |
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MedLine Citation:
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PMID: 21545852 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of this study was to determine the relationship between airway blood flow (Q(aw)), airway conductance (G(f-aw)) and pulmonary function in patients with stable HF. METHODS: 12 controls (CTRL: age=63±9 years, FVC=98±15%pred, LVEF=61±6%) (all data presented as mean±SD), 16 patients with mild HF (HF-A, NYHA I-II: age=64±9 years, FVC=90±17%pred, LVEF=28±6%), and 14 patients with moderate/severe HF (HF-B, NYHA III-IV: age=65±6 years, FVC=84±12%pred, LVEF=26±6%) were studied. Q(aw) was assessed using soluble gas measurements; perfusion pressure across airway bed (ΔP(aw)) was estimated from systemic and pulmonary pressure measurements; G(f-aw) was calculated as Q(aw)/ΔP(aw); PF was assessed by spirometry. RESULTS: While Q˙(aw) was not significantly different between CTRL (61.3±17.9 μL min(-1)mL(-1)), HF-A (70.1±26.9 μL min(-1)mL(-1)) and HF-B (56.2±14.9 μL min(-1)mL(-1)) groups, G(f-aw), was elevated in HF-A (1.1±0.4 μL min(-1)mL(-1)mm Hg(-1), p<0.03) and tended to be elevated in HF-B (1.2±0.6 μL min(-1)mL(-1)mm Hg(-1), p=0.07) when compared to CTRL (0.8±0.3 μL min(-1)mL(-1)mm Hg(-1)). Significant positive correlations were found between G(f-aw) and RV/TLC for HF-A (r=0.63, p<0.02) and HF-B (r=0.58, p<0.05). CONCLUSIONS: These results support the hypothesis that increased bronchial conductance and bronchial congestion may be related to greater small airway obstruction and as such may play a role in the PF abnormalities and symptoms of congestion commonly observed in HF patients. |
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Authors:
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Maile L Ceridon; Norman R Morris; Minelle L Hulsebus; Thomas P Olson; Sophie Lalande; Bruce D Johnson |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-04-27 |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: 177 ISSN: 1878-1519 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-06-20 Completed Date: 2011-10-25 Revised Date: 2013-03-28 |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 256-64 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Analysis of Variance Blood Gas Analysis Blood Pressure / physiology Bronchi / blood supply* Case-Control Studies Echocardiography / methods Female Heart Failure, Systolic / pathology*, physiopathology* Hemodynamics Humans Male Middle Aged Pulmonary Circulation / physiology* Respiratory Function Tests Spirometry / methods Vital Capacity / physiology |
| Grant Support | |
ID/Acronym/Agency:
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1 UL1 RR024150/RR/NCRR NIH HHS; HL71478/HL/NHLBI NIH HHS; R01 HL071478-01S1/HL/NHLBI NIH HHS; R01 HL071478-09/HL/NHLBI NIH HHS |
| Comments/Corrections | |
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