Document Detail


Influence of bronchial blood flow and conductance on pulmonary function in stable systolic heart failure.
MedLine Citation:
PMID:  21545852     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The aim of this study was to determine the relationship between airway blood flow (Q(aw)), airway conductance (G(f-aw)) and pulmonary function in patients with stable HF.
METHODS: 12 controls (CTRL: age=63±9 years, FVC=98±15%pred, LVEF=61±6%) (all data presented as mean±SD), 16 patients with mild HF (HF-A, NYHA I-II: age=64±9 years, FVC=90±17%pred, LVEF=28±6%), and 14 patients with moderate/severe HF (HF-B, NYHA III-IV: age=65±6 years, FVC=84±12%pred, LVEF=26±6%) were studied. Q(aw) was assessed using soluble gas measurements; perfusion pressure across airway bed (ΔP(aw)) was estimated from systemic and pulmonary pressure measurements; G(f-aw) was calculated as Q(aw)/ΔP(aw); PF was assessed by spirometry.
RESULTS: While Q˙(aw) was not significantly different between CTRL (61.3±17.9 μL min(-1)mL(-1)), HF-A (70.1±26.9 μL min(-1)mL(-1)) and HF-B (56.2±14.9 μL min(-1)mL(-1)) groups, G(f-aw), was elevated in HF-A (1.1±0.4 μL min(-1)mL(-1)mm Hg(-1), p<0.03) and tended to be elevated in HF-B (1.2±0.6 μL min(-1)mL(-1)mm Hg(-1), p=0.07) when compared to CTRL (0.8±0.3 μL min(-1)mL(-1)mm Hg(-1)). Significant positive correlations were found between G(f-aw) and RV/TLC for HF-A (r=0.63, p<0.02) and HF-B (r=0.58, p<0.05).
CONCLUSIONS: These results support the hypothesis that increased bronchial conductance and bronchial congestion may be related to greater small airway obstruction and as such may play a role in the PF abnormalities and symptoms of congestion commonly observed in HF patients.
Authors:
Maile L Ceridon; Norman R Morris; Minelle L Hulsebus; Thomas P Olson; Sophie Lalande; Bruce D Johnson
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-04-27
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  177     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-06-20     Completed Date:  2011-10-25     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  256-64     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Affiliation:
Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Analysis of Variance
Blood Gas Analysis
Blood Pressure / physiology
Bronchi / blood supply*
Case-Control Studies
Echocardiography / methods
Female
Heart Failure, Systolic / pathology*,  physiopathology*
Hemodynamics
Humans
Male
Middle Aged
Pulmonary Circulation / physiology*
Respiratory Function Tests
Spirometry / methods
Vital Capacity / physiology
Grant Support
ID/Acronym/Agency:
1 UL1 RR024150/RR/NCRR NIH HHS; HL71478/HL/NHLBI NIH HHS; R01 HL071478-01S1/HL/NHLBI NIH HHS; R01 HL071478-09/HL/NHLBI NIH HHS
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